hif-2α调控mir-191在亚砷酸钠所致细胞恶性转化中的作用及机制研究

《hif-2α调控mir-191在亚砷酸钠所致细胞恶性转化中的作用及机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、南京医科大学博士学位论文分类号：R113单位代码：10312密级：学号：20122065博士学位论文题目：HIF-2α调控miR-191在亚砷酸钠所致细胞恶性转化中的作用及机制研究研究生：徐文超指导教师：刘起展教授学科专业：卫生毒理学学院名称：公共卫生学院完成时间：二〇一五年五月南京医科大学博士学位论文南京医科大学学位论文原创性声明本人郑重声明：所呈交的论文是本人在导师的指导下，独立进行研究工作所取得的成果。除了文中特别加以标注引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写的成果作品。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明。本

2、人完全意识到本声明的法律后果由本人承担。作者签名：日期：年月日导师签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权南京医科大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本学位论文属于（请务必在以下相应方框内打“√”）：1、保密□，在年解密后适用本授权书。2、不保密□。作者签名：日期：年月日导师签名：日期：年月日南京医科大学博士学位论文目录缩略语·······

3、···················································································1中文摘要··························································································3英文摘要························································································10引言·········

4、···············································································18第一部分miR-191调控EMT和CSCs特性获得在亚砷酸钠所致HBE细胞恶性转化中的作用·····································································22材料方法···········································································23结果····

5、······································································39讨论··········································································55第二部分HIF-2α调控miR-191在亚砷酸钠所致恶性转化HBE细胞的血管生成和转移中的作用··································································62材料方法···············

6、···························································63结果··········································································69讨论··········································································79结束语································································

7、························84参考文献························································································88文献综述·······················································································103附录····································································

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