表没食子儿茶素没食子酸酯烷基化衍生物合成及抑制肝癌细胞增殖的初步研究

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1、学校代码：10600学号：101079学位类型：科学学位广西中医药大学硕士学位论文表没食子儿茶素没食子酸酯烷基化衍生物合成及抑制肝癌细胞增殖的初步研究研究生：周焕第导师：李丽副教授院系（部所）：药学院专业：药理学研究方向：生化药理研究完成日期：2013年5月28日目录英文缩略词表·············································1中文摘要·················································2英文摘要···························

2、······················4引言·················································6正文·················································7第一部分乙基化EGCG和丙基化EGCG的化学合成············71主要仪器与试剂··········································72实验方法与结果··········································73分析与讨

3、论··············································9第二部分乙基化EGCG和丙基化EGCG的分离、纯化··········131主要仪器与试剂·········································132实验方法与结果·········································143分析与讨论·············································21第三部分乙基化EGCG和丙基化EGCG的结构确证·······

4、···221主要仪器···············································222测定方法···············································223测定结果及综合解析·····································224解析结果与讨论·······································30第四部分EGCG衍生物抑制肝癌细胞SMMC-7721,HepG2增殖的实验研究·····················

5、···························321实验材料···············································322测定内容···············································343统计学方法··········································344实验方法···············································345实验结果·························

6、······················376分析与讨论·············································44第五部分EGCG及衍生物5,3´,4´,3″,4″,5″-六-O-乙基-EGCG（y6）增效柔红霉素抑制肝癌细胞的比较研究·················461实验材料···············································462测定内容···············································473统计学方法

7、···········································474实验方法···············································475实验结果·············································506分析与讨论·············································56结论················································56结语与展望··········

8、····································57参考文献················································58附图·········