山莨菪碱对大鼠横纹肌溶解致急性肾损伤时内质网应激的影响

《山莨菪碱对大鼠横纹肌溶解致急性肾损伤时内质网应激的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号：R692.5;R873密级：公开山莨菪碱对大鼠横纹肌溶解致急性肾损伤时内质网应激的影响Effectofanisodamineonendoplasmicreticulumstressduringrhabdomyolysis-inducedacutekidneyinjuryinrats作者姓名：赵维学科专业：内科学导师：吴广礼答辩委员会主席：论文答辩日期：年月日院校地址：北京市复兴路28号邮政编码：100853解放军医学院研究生学位论文原创性声明秉承我院“忠诚、敬业、和谐、创新”的学风，本人声明：所呈交的论文是我本人在导师指导下进行的研究工作及取得的研究成果。据我所知，除了文中特别加以

2、标注和致谢的地方外，论文中不包含任何其他个人或集体已经发表或撰写过的研究成果，也不含为获得我院或其他教育机构的学位及证书而使用过的材料，对本文的研究作出贡献的个人或集体，均已在文中做了明确的说明并表示谢意。申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：指导教师签名：日期：解放军医学院研究生学位论文版权使用授权书本人保证毕业离院后，发表论文或使用论文工作成果时署名单位为解放军医学院或解放军总医院。学院有权保留并向国家有关部门或机构送交论文原件、复印件和电子版本，可以采用影印、缩印、扫描或其它手段保存论文以供被查阅和借阅。学院可以公布学位论文的全部或部分内容（保密内

3、容除外）。论文作者签名：日期：指导教师签名：日期：解放军医学院硕士学位论文目录中文摘要············································································1英文摘要············································································3前言············································································5正文················

4、····························································7材料············································································7方法············································································9结果··········································································12讨

5、论··········································································16结论··········································································18附图··········································································19参考文献·····························································

6、·············27文献综述内质网应激与肾脏疾病·········································29附录英文缩略词表·····················································39攻读学位期间发表文章情况··················································41致谢··········································································43解放军医学院硕士学位论文解放军医学院硕士学

7、位论文中文摘要作者：赵维学科专业：内科学导师：吴广礼山莨菪碱对大鼠横纹肌溶解致急性肾损伤时内质网应激的影响中文摘要背景与目的本课题组以往研究表明，过度训练可导致大鼠横纹肌溶解，进而导致急性肾损伤(AKI)，其中细胞凋亡机制发挥着重要作用，山莨菪碱可通过抑制细胞凋亡发挥肾保护作用，而山莨菪碱抗凋亡的具体作用机制值得探讨。研究表明，当细胞暴露于缺氧、营养缺乏、氧化应激、蛋白质异常糖基化反应以及钙稳态失衡等因素时，会导致内质网