白杨素对实验性脑梗死大鼠脑保护作用与其机制的分析

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1、英文摘要TheneuroprotectiVeeffectofchrysinandtheunderlyingmechanisminexperimentalischemicstrokeABSTRACTObjectives：Cerebrovasculardisease，cancer,heartdiseaseiSthethreediseasesindevelopingcountriesinthecauseofhumandisabilityanddeath．schemicstrokeisthemostcommon，accountingforabout80％to85％ofal

2、lcerebrovasculardisease．SecondarybraindamagefollowingcerebralischemiaCanleadtoexacerbations．andaffecttheprognosis．ThemechanismofSecondarybraindamageisverycomplex，includingenergydepletionandacidosis，oxygenfreeradicals，intracellularCa2+overload，damageofexcitatoryaminoacidtoxicity,inflam

3、matorycytokines，apoptosisandSOon．It’Swellknownthattheinflammatoryresponseandapoptosisplaysakeyroleincerebralischemicpathogenesis．Nuclearfactor-kappaB(NF-rd3)isaubiquitouslyexpressedtranscriptionfactor，whichregulateshundredsofgenesinvolvedincellsurvivalandinflammation．Thereisampleevide

4、ncethatNF—KBisactivatedincerebralischemia，mainlyinneurons．ItisknownthatseveralproinflammatoryNF一1出targetgenes(XNF，IL—laandp，IL一6，iNOS，ICAM-1，COX一2，PLA2andMMP9)areinducedincerebralischemia，possiblycontributingtoischemicdamage．Neuronsrespondtohypoxiacausedbyischemiabytriggeringadynamicn

5、etworkofsignalingpathwaysincludingthemitogen-activatedproteinkinases(MAPKs)．TheMAPKswhichareafamilyofrelatedserine／threoninekinasesandsignaltransductionmediatorsincludestheextracellularsignal—regulatedkinases(ERK)andthestress。activatedproteinkinases(suchasJNK／SAPK1andp38／SAPK2)．ERKsre

6、gulatemultiplefunctionsthatcontaincellgrowth，proliferation，differentiationandapoptosis．TheERKl／2moduleisprimarilyactivatedinresponsetogrowthfactors，oxidativestress，increasesofintracellularCa2+levelsandalsotoglutamatereceptorstimulation，factorswhichareactivated4一英文摘要———————————————————

7、—————————二．_二二-————一bystroke．JNKandp38arealsoactivatedbyenvironmentalstressandinflammatorycytokines．Activationofp38andJNKplaysimportantrolesintransducingstress‘relatedsignalsinvolvedincellsurvival，apoptosisandinflammatorycytokineproduction．TheMAPKscontrolmultitudinousIntracellulareven

8、tsinr