黄体酮对脑梗死大鼠血脑屏障保护作用的机制分析

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1、虫毫摘要原的降解，实现其降低血脑屏障通透性及减轻脑水肿程度的作用。关键词黄体酮脑梗死血脑屏障基质金属蛋白酶一9金属蛋白酶组织抑制剂一1Ⅳ型胶原IVAbstractResearchonMechanismofProgesteroneProtectingBloodBrainBarrierafterCerebralInfarctioninRatsPostgraduate：YujinHaoSupervisor：JingpingWangDepartmentofNeurologyTheFifthClinicalCollegeofZhengzhouUnive

2、rsityZhengzhou，Henan，450000，ChinaBackgroundand0bjectiveCerebralinfarctionisakindoffrequentlyencountereddiseasesinnervoussystem．Rhasthreecharacteristics：hilghincidence,hi．ghmortalityandhighdisabilityrate．AlthougharterialandVenOUSthrombolytictherapiesshowtheirsatisfactoryther

3、apeuticvalue'theirtherapeutictimewindowsareverynarrowthatconstrictstheirapplicationinclinicaltherapy．Soitisofgreatsignificancetodevelopnewtherapeuticdrug．Thephysicalandpathologicalprocessofcerebralinfarctionisverycomplex．Itincludesexcitotoxicity,oxidativestress，calciumoverl

4、oad,andSOon．11地mentionedf批rsallCanleadtoneuronaldeathandbreakdownoftheintegrityofBloodBrainbarrier(BBB)．Thelatterplaysallimportantroleinthepathologicalprocess’ofcerebralinfarction,whichisdosdycorrelatedwithincreasedpermeabilityofmierovessel，hemorrhagictransformationaftercer

5、ebralinfarction,brainedemaanddamageofminicirculation．CollagenIVisanimportantcategoryofingredientsinmicrocirculatorybasementmembrane，SOitsquantitybecomeavitalindexinevaluatingthebreakdownofBBB．ResearchindicatedthattheimbalanceofMMPs／TIMPsisdosdyrelatedwiththebreakdownoftheba

6、sementmembraneofVBBB．SoregulatingexpressionofMMPsandTIMPsmayplayallimportantroleinmaintainingtheintegrityofthebasementmembraneofBBB．Latelystudiesinforeigncountriesshowedthatthemedicatingprogesteronehasimportantvalueintreatmentinbraininjury．Itnotonlygreatlyrelievetheextentof

7、brainedema,butalsopromotetherecoveryofRa'VOILSfunction．However,themechanismofprogesteronealleviatingtheextentofbrainedemaisnotclear．Toprobeintotheneuroprotectiveeffectofprogesteroneandsupplytheoreticalfoundationforitsclinicalapplication．pMACO(permanentmiddlecerebralarteryoc

8、clusion)modelWasemployedinthisstudy,whoseprocessofcerebralinfarctionissimilartotha