川陈皮素对实验性脑梗死大鼠脑保护作用与其对p-akt、p-creb、dbnf、bcl-2和claudin-5调节作用的实验分析

《川陈皮素对实验性脑梗死大鼠脑保护作用与其对p-akt、p-creb、dbnf、bcl-2和claudin-5调节作用的实验分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、英文摘要Theneuroprotectiveeffectofnobiletininexperimentalischemicstrokeanditsregulationonp-Akt，p-CREB，BDNF，Bcl一2andClaudin．．5ABSTRACTobjectives：Ischemicstrokeremainsaleadingcauseofdeathandacquireddisabilityworldwideinadults．Cerebralischemia，inducedbyareductionorcompleteblockadeofbloodflowtoregionso

2、fthebrain，isaccompaniedwithaninterdependentseriesofeventsincludingglutamateexcitotoxicity，calciumoverload，oxidativestress，nitricoxideproductionandinflammation，eventuallyleadingtocelldeath．DespitetheadministrationofintravenousthrombolysisiScurrentlyapprovedforacuteischemicstroke，itsclinicalappli

3、cationisstilllimitedduetothenarrowtherapeuticwindowandsafetyconcerns．Therefore，explorationofnoveltherapeuticagentsbecomesamajorchallengeinthefield．Theserine／threoninekinaseAktiSakeydownstreameffectorofthephosphoinositide．3．kinasepathway．TheAktactivatesandphosphorylatesCREBatSerl33，resultinginth

4、eup—regulationofpro—survivalCI迮BtargetgenessuchasB【小限andBcl．2．Thus，Akt／CREBsignalingpathwaymaybeonepropitioustargetfortreatmentofischemiccerebralinjury．NOB，acitruspolymethoxyflavonoid，ismainlyextractedfromatraditionalherbalmedicinepericarpiumcitrireticulataeandisabundantly。thfruitoericartofCitr

5、us．IntraditionalCh"medicinedriedpresentintheti'uitperlcarpotltrusIntraaltlonaltsnlnesemealclne,orleo●citrusfruitpeelsarewidelyusedasremediestoalleviatestomachupset，respiratoryinflammatorysyndromesandringworminfections．NOBhasattractedpeople’SaRentionduetoitsversatilehealth—promotingpropertiesinc

6、ludinganti．inflammatory，antioxidantandanticarcinogenicactivities．Furthermore，NOBalsodisplayedanti-atherogenic，anti—diabetic，hepatic．protectiveandneurotrophiceffects．However．1ittleiScurrentlyknown4英文摘要regardingtheexactroleofNOBinischemicstrokeandtheunderlyingmechanisms．Thisexperimentsuccessfully

7、establishedthemodelofpermanentmiddlecerebralarteryocclusioninrats．Neurologicaldeficitscores，infarctvolume，andbrainwatercontentwereevaluatedat24hafterstroke．Additionally，theactivitiesofAkt，CREB，BDNF，Bcl一2andclaudin一5inischemicbrain