急性心肌梗死患者溶栓后血浆中脑钠素浓度变化的研究

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1、维普资讯http://www.cqvip.com·168中华老年心脑血管病杂志2006年3月第8卷第3期OlnJGerlatrHeartnl'ai$

2、VesselDis，Mar2006．Vol8。No．3．临床研究．急性心肌梗死患者溶栓后血浆中脑钠素浓度变化的研究赵雅琳，蒋宝国(1．沈阳医学院奉天医院，辽宁沈阳110024；2．中国医科大学附属第四医院，辽宁沈阳110032)摘要：目的研究血中脑钠素(BNP)水平与急性心肌梗死溶栓后左心室射血分数(LVEF)和心肌缺血程度的关系。方法将198例顺序入选的急性心肌梗死行链激酶静脉溶栓治疗的患者分为溶栓成功组(105例)和溶栓未成功组(93例

3、)，检测所有患者的血BNP水平及测定LVEF，比较溶栓成功组与溶栓未成功组LVEF>40％和LVEF~<40％的BNP水平。结景溶栓成功组BNP水平明显低于溶栓未成功组的BNP水平(725．4土169．8)ng／L(P<0．05)，溶栓成功组和未成功组中LvEF>40％患者的BNP水平[(107．7土46．5)I1g／L，(488．5土88．9)ng／L]明显低于LVEF~<40％患者的BNP水平[(515．5±121．2)l1g，L，(856．7土129．5)ng／L，P

4、疗法；危险因素中图分类号：R542．22文献标识码：A文章编号：1009—0126(2006103—016803PlasmalevelsofbrainnatriureticpeptideinacutemyocardialinfarctionpatientsafterthrombolysisZHAOYa—lin，JIANGBao—guo(OepaamentofCardiology，FengtlanHospitalAJfiliatedtoShenyangMedicalCollege，Shenyang110024，Ch／na)Abstract：ObjectiveToinvestigatethe

5、relationshipbetweenplasmalevelsofbrainnatriureticpeptide(BNP)andleftventricularejectionfraction(LVEF)anddegreeofmyocardialischemiainpatientswithacutemyocar—dialinfarction(AMI)afterthrombolytictherapy．Methods198AMIpatientstreatedwithintravenousthrum—bolysiswererandomlydividedintotwogroups．BNPconce

6、ntrationofcoronaryrepatencygroupWascomparedththatofmyocardialisehemiagroup，andthatofLVEF>40％withthatofLVEF~<40％patientsrespective—lyintwogroups．ResultsPlasmaBNPconcentrationincoronaryrepatencygroupWassignificantlylowerthanthatinmyocardialischemlagroup[(327．9土85．4)(725．4±169．8)ng／L，P<0．05]．Ineomna

7、ryrepa—tencygroup，plasmaBNPconcentrationWas(107．7±46．5)ng／LinLVEF>40％patientsand(515．5-4-121．2)nggLinLVEF_<_40％patients．Inmyocardialisehemiagroup，plasmaBNPconcentrationinLVEF>40％patientswassignificantlylowerthanthatinLVEF~<40％patients[(488．5±88．9)ng／L(856．7-4-129+5)nggL](P

8、NPconcentrationisrelatedtoLVEFandthedegreeofmyocardialisehemiaafterthrombolytietherapyforacutemyocardialinfarction．Keywords：CDDCDDCDDCDDmyocardialinfarction；natriureticpeptide，brain；thmmbolytietherapy；riskfactors近年来，急诊