天钩降压胶囊中丹皮酚、天麻苷药动学的研究论文

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1、Pharmacokineticsofpaeonol、gastrodinfromTiangouJiangyacapsuleinratsSpeciality：TraditionalChineseMedicineAuthor：WangYinglanTutor：LiLingjunAbstractObjective:StudytheintragastricofTiangouJiangyaCapsuleonthepharmacokineticsofpaeonol、gastrodininrats.Methods:Thecontentsofpaeonolinp

2、lasma、gastrodinweredeterminedbyHPLCmethod.Themeanplasmaconcentration-timecurvesofdifferentmedicationadministrationteamswereanalyzedwithDAS2.0software.PharmacokineticparametersbetweengroupswerestatisticalanalyzedbySPSS16.0.Results:Theplasmaconcentrationofpaeonolwasbeyondthemi

3、nimumdetectionlimitandtheplasmaconcentration-timecurvefailedtodetectatlowdosagegroup.ThemaximumabsorptionofmiddleandhighdosagesofPaeonolreachedthemaximumabsorptionin5minute；ti/2ka，Cmax，AUCo-oo，AUCo-36o，CLz/Fincreasedsignificantlywithincreasingofintragastricadministrationdosa

4、ges.t]/2Z，MRTo-360，Vz/Freducedsignificantlywithreducingofintragastricadministrationdosages；Compoundgroupcomparedwithsingleproductgroup,therewasnosignificantdifferenceinAUCq-o：andTmax,butCmax、MRTo~36o、U/2z、Vz/Finthecompoundgroupdecreasedsignificantly.t1/2kainthecompoundgroupi

5、ncreasedsignificantly.Thepharmacokineticsinvivoofgastrodintheconcentration-timecurvefittedtoatwocompartmentmodel.tl/2ka=9.291±9.149，tI/2尸191.082士164.107，itmeansgastrodininvivoabsorptionfastandeliminateslow.C跳、=119.057士29.458，itmeanstheplasmaconcentrationrelativehigh.Itisabou

6、tonehourreachedthemaximumadsorption.Conclusions:PharmacokineticsparameterexistingcertaindifferencesafterintragastricadministrationofdifferentdosagesofTiangouJiangyaCapsule.Compoundcompositioneffectpaeonolpharmacokineticsparameters.Thepharmacokineticsinvivoofgastrodintheconce

7、ntration-timecurvefittedtoatwocompartmentmodel.KeywordsTiangouJiangyacapsule；pharmacokinetics；HPLC；paeonol；gastrodin目录弓丨g1第一部分文献综述21中药药代动力学研究现状21.1单味中药21.2中药复方或有效部位的药代动力学研究21.3方剂配伍作用机制研究31.4中西药药代动力学相互作用研究41.5不同剂型的药代动力学比较研究51.6对代谢酶的影响研究61.7利用PK-PD模型进行的研究62丹皮酚综述72.1丹皮酚理化性质72.2

8、丹皮酚药理研究72.3丹皮酚药动学研究现状73天麻苷综述83.1天麻苷理化性质83.2天麻苷药理研究83.3天麻苷药动学研究现状8第二部分天钩降压胶囊