天钩降压胶囊中丹皮酚、天麻苷的药动学研究

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1、提要目的：研究天钩降压胶囊中丹皮酚、天麻苷在大鼠体内的药代动力学。方法：采用HPLC法测定丹皮酚、天麻苷血药浓度，各给药组平均血药浓度-时间数据采用DAS2.0软件分析，组间药动学参数用SPSS16.0软件进行统计分析。结果：低剂量组大鼠丹皮酚血药浓度在消除相超出最低检测限，未能测出药-时曲线；中、高剂量组丹皮酚均在5min达最大吸收；t1/2ka，Cmax，AUCo-oo,AUCG.36G,CLz/F随给药剂量增加而显著性增加；t1/2z，MRTO-360-VZ/F随给药剂量增加而显著性减小；复方组与单品组比较，AUCh和T■无显著性差异，但复方组(：匪、MRTo-3

2、6o、t1/2z、Vz/F显著性减小，t1/2ka显著性增加。天麻苷体内药动学符合二室模型，药动学参数t临为9.291士9.149，t1/2z为191.082±164.107，吸收快，消除慢；CU、为119.057士29.458，血药浓度相对较高；lh左右达到最大吸收。结论：大鼠灌胃不同剂量天钩降压胶囊后丹皮酚的药动学参数存在一定差异，复方成分可影响丹皮酚的药动学参数；天麻苷体内药动学符合二室模型。关键词天钩降压胶囊；药代动力学；HPLC;丹皮酚；天麻苷tPharmacokineticsofpaeonol、gastrodinfromTiangouJiangyacapsu

3、leinratsSpeciality：TraditionalChineseMedicineAuthor：WangYinglanTutor：LiLingjunAbstractObjective:StudytheintragastricofTiangouJiangyaCapsuleonthepharmacokineticsofpaeonol、gastrodininrats.Methods:Thecontentsofpaeonolinplasma、gastrodinweredeterminedbyHPLCmethod.Themeanplasmaconcentration-ti

4、mecurvesofdifferentmedicationadministrationteamswereanalyzedwithDAS2.0software.PharmacokineticparametersbetweengroupswerestatisticalanalyzedbySPSS16.0.Results:Theplasmaconcentrationofpaeonolwasbeyondtheminimumdetectionlimitandtheplasmaconcentration-timecurvefailedtodetectatlowdosagegroup

5、.ThemaximumabsorptionofmiddleandhighdosagesofPaeonolreachedthemaximumabsorptionin5minute；ti/2ka，Cmax，AUCo-oo，AUCo-36o，CLz/Fincreasedsignificantlywithincreasingofintragastricadministrationdosages.t]/2Z，MRTo-360，Vz/Freducedsignificantlywithreducingofintragastricadministrationdosages；Compou

6、ndgroupcomparedwithsingleproductgroup,therewasnosignificantdifferenceinAUCq-o：andTmax,butCmax、MRTo~36o、U/2z、Vz/Finthecompoundgroupdecreasedsignificantly.t1/2kainthecompoundgroupincreasedsignificantly.Thepharmacokineticsinvivoofgastrodintheconcentration-timecurvefittedtoatwocompartmentmod

7、el.tl/2ka=9.291±9.149，tI/2尸191.082士164.107，itmeansgastrodininvivoabsorptionfastandeliminateslow.C跳、=119.057士29.458，itmeanstheplasmaconcentrationrelativehigh.Itisaboutonehourreachedthemaximumadsorption.Conclusions:Pharmacokineticsparameterexistingcertaindifferencesafterint