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ID:33936372
大小:6.89 MB
页数:48页
时间:2019-03-01
《天钩降压胶囊中丹皮酚、天麻苷药动学的研究论文》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、Pharmacokineticsofpaeonol、gastrodinfromTiangouJiangyacapsuleinratsSpeciality:TraditionalChineseMedicineAuthor:WangYinglanTutor:LiLingjunAbstractObjective:StudytheintragastricofTiangouJiangyaCapsuleonthepharmacokineticsofpaeonol、gastrodininrats.Methods:Thecontentsofpaeonolinp
2、lasma、gastrodinweredeterminedbyHPLCmethod.Themeanplasmaconcentration-timecurvesofdifferentmedicationadministrationteamswereanalyzedwithDAS2.0software.PharmacokineticparametersbetweengroupswerestatisticalanalyzedbySPSS16.0.Results:Theplasmaconcentrationofpaeonolwasbeyondthemi
3、nimumdetectionlimitandtheplasmaconcentration-timecurvefailedtodetectatlowdosagegroup.ThemaximumabsorptionofmiddleandhighdosagesofPaeonolreachedthemaximumabsorptionin5minute;ti/2ka,Cmax,AUCo-oo,AUCo-36o,CLz/Fincreasedsignificantlywithincreasingofintragastricadministrationdosa
4、ges.t]/2Z,MRTo-360,Vz/Freducedsignificantlywithreducingofintragastricadministrationdosages;Compoundgroupcomparedwithsingleproductgroup,therewasnosignificantdifferenceinAUCq-o:andTmax,butCmax、MRTo~36o、U/2z、Vz/Finthecompoundgroupdecreasedsignificantly.t1/2kainthecompoundgroupi
5、ncreasedsignificantly.Thepharmacokineticsinvivoofgastrodintheconcentration-timecurvefittedtoatwocompartmentmodel.tl/2ka=9.291±9.149,tI/2尸191.082士164.107,itmeansgastrodininvivoabsorptionfastandeliminateslow.C跳、=119.057士29.458,itmeanstheplasmaconcentrationrelativehigh.Itisabou
6、tonehourreachedthemaximumadsorption.Conclusions:PharmacokineticsparameterexistingcertaindifferencesafterintragastricadministrationofdifferentdosagesofTiangouJiangyaCapsule.Compoundcompositioneffectpaeonolpharmacokineticsparameters.Thepharmacokineticsinvivoofgastrodintheconce
7、ntration-timecurvefittedtoatwocompartmentmodel.KeywordsTiangouJiangyacapsule;pharmacokinetics;HPLC;paeonol;gastrodin目录弓丨g1第一部分文献综述21中药药代动力学研究现状21.1单味中药21.2中药复方或有效部位的药代动力学研究21.3方剂配伍作用机制研究31.4中西药药代动力学相互作用研究41.5不同剂型的药代动力学比较研究51.6对代谢酶的影响研究61.7利用PK-PD模型进行的研究62丹皮酚综述72.1丹皮酚理化性质72.2
8、丹皮酚药理研究72.3丹皮酚药动学研究现状73天麻苷综述83.1天麻苷理化性质83.2天麻苷药理研究83.3天麻苷药动学研究现状8第二部分天钩降压胶囊
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