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ID:33792472
大小:5.33 MB
页数:41页
时间:2019-03-01
《婴儿胆道畸形与巨细胞病毒感染的临床病理分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、重庆医科大学硕士学位论文婴儿胆道畸形与巨细胞病毒感染的临床病理分析姓名:陈肯申请学位级别:硕士专业:儿科学指导教师:康权201205重庆医科大学硕士研究生学位论文婴儿胆道畸形与巨细胞病毒感染的临床病理分析摘要目的:探讨婴儿胆道畸形(胆道闭锁、胆道狭窄)与巨细胞病毒感染的关系,了解胆道畸形合并巨细胞病毒感染在临床表现、肝功能、病检结果上的特点。方法:回顾性分析我院收治,经手术造影证实的48例胆道畸形患儿临床资料,根据巨细胞病毒感染与否将病人分组,比较两组患儿在肝功能,肝脏活检病检结果上的异同。结果:1.48例胆道畸形患儿中,合并巨细胞病毒感染22例,占45.8
2、%。37例胆道闭锁患儿中,感染组17例与非感染组20例的7-GT、ALP及小胆管增生程度有显著性差异(尸3、汇管区小胆管增生程度。2.小胆管增生程度与胆汁淤积程度和胆管上皮细胞受损的严重程度存在相关性。关键词:巨细胞病毒;胆道畸形;肝功能;病理学重庆医科大学硕士研究生学位论文THECLINICoPATHoLoGICSTUDYoNINFf蝌TILEBILIARYM队LFoRML气TIoNANDCYToMEGALoVIRUSobjective:INFECTIONABSTRACTToinvestigatetherelationshipbetweencytomegalovirus(CMV)infectionandbiliarymalformation(biliaryatr4、esia,biliarystricture)andtoevaluatethefeaturesofclinicalmanifestation,liverfunctionandpathologicchangesinpatientswithbiliarymalformationassociatedwithCMVinfection.Methods:Thedatafrom48patiemswithbiliarymalformationwhichwereconfirmedbysurgeryandcholangiographyinourhospitalwereretros5、pectivelyreviewed.AccordingtowhetherinfectedwithCMV,thepatientswereclassifiedintoCMVinfectedgroupandnon-infectedgroup.Theliverfunctionandpathologicchangesofliverbiopsyspecimenswerecomparedbetweenthegroups.Result:1.In48caseswithbiliarymalformation,therewere22casesassociatedwithCMVin6、fection,accountingfor45.8%.In37caseswithbiliaryatresia,4重庆医科大学硕士研究生学位论文thelevelsofY-GT,ALPandbileductularproliferationweresignificantlyhigherininfectedgroup(n217)thanthoseinnon-infectedgroup(n=20)(P<0.05).In1caseswithbiliarystricture,therewasnosignificantdifferenceoflevelsofliverfu7、nctionandbileductularproliferationbetweeninfectedgroup(n25)andnon-infectedgroup(n=6).2.ThelevelsofY-GTandbileductularproliferationweresignificantlyhigherincaseswithbiliaryatresia(n=37)thanthoseincaseswithbiliarystricture(n211)(P8、ratebetweenthegroups.In48c
3、汇管区小胆管增生程度。2.小胆管增生程度与胆汁淤积程度和胆管上皮细胞受损的严重程度存在相关性。关键词:巨细胞病毒;胆道畸形;肝功能;病理学重庆医科大学硕士研究生学位论文THECLINICoPATHoLoGICSTUDYoNINFf蝌TILEBILIARYM队LFoRML气TIoNANDCYToMEGALoVIRUSobjective:INFECTIONABSTRACTToinvestigatetherelationshipbetweencytomegalovirus(CMV)infectionandbiliarymalformation(biliaryatr
4、esia,biliarystricture)andtoevaluatethefeaturesofclinicalmanifestation,liverfunctionandpathologicchangesinpatientswithbiliarymalformationassociatedwithCMVinfection.Methods:Thedatafrom48patiemswithbiliarymalformationwhichwereconfirmedbysurgeryandcholangiographyinourhospitalwereretros
5、pectivelyreviewed.AccordingtowhetherinfectedwithCMV,thepatientswereclassifiedintoCMVinfectedgroupandnon-infectedgroup.Theliverfunctionandpathologicchangesofliverbiopsyspecimenswerecomparedbetweenthegroups.Result:1.In48caseswithbiliarymalformation,therewere22casesassociatedwithCMVin
6、fection,accountingfor45.8%.In37caseswithbiliaryatresia,4重庆医科大学硕士研究生学位论文thelevelsofY-GT,ALPandbileductularproliferationweresignificantlyhigherininfectedgroup(n217)thanthoseinnon-infectedgroup(n=20)(P<0.05).In1caseswithbiliarystricture,therewasnosignificantdifferenceoflevelsofliverfu
7、nctionandbileductularproliferationbetweeninfectedgroup(n25)andnon-infectedgroup(n=6).2.ThelevelsofY-GTandbileductularproliferationweresignificantlyhigherincaseswithbiliaryatresia(n=37)thanthoseincaseswithbiliarystricture(n211)(P8、ratebetweenthegroups.In48c
8、ratebetweenthegroups.In48c
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