细胞色素c对庆大霉素、依替米星致大鼠肾小管毒性的预防作用研究

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1、目录英文缩略词表（Abbreviations）·······························1中文摘要···················································2英文摘要（Abstract）········································5前言·····················································9第一部分细胞色素C对庆大霉素致大鼠肾小管毒性的预防作用研究1仪器与材料·······························

2、·············112方法··················································123结果··················································144讨论··················································175结论··················································20第二部分细胞色素C对依替米星致大鼠肾小管毒性的预防作用研究1仪器与材料··················

3、··························212方法··················································223结果··················································254讨论··················································335结论··················································36参考文献····································

4、··············37附录····················································44致谢····················································45综述中药防治药源性肾毒性的研究现状··························47参考文献（综述部分）······································81英文缩略词表（Abbreviations）英文缩写英文全称中文名称AGsaminoglycosides氨基糖苷类抗生素AINacu

5、teinterstitialnephritis急性间质性肾炎AKIacutekidneyinjury急性肾功能损伤Apaf-1apoptotisproteaseactivatingfactor-1凋亡蛋白酶活化因子-1ARFacuterenalfailure急性肾功能衰竭BUNbloodureanitrogen血尿素氮CKFchronickidneyfailure慢性肾功能衰竭Crcreatinine肌酐DINdruginducednephrotoxicity药源性肾毒性FPIAfluorescencepolarizationimmunoassay荧光偏振免疫分析GFR

6、glomerularfiltrationrate肾小球滤过率HPLChighperformanceliquidchromatography高效液相色谱法LDLRlow-densitylipoproteinreceptor低密度脂蛋白受体MDAmalondialdehyde丙二醛CMIAS-IIColorMedicalImageAnalysisSystem-II真彩色医学图像分析系统mPTPmitochondrialpermeabilitytransitionpore线粒体膜通透性转换孔MRSAmethicillin-resistantStaphylococcusaure

7、us耐甲氧西林金葡菌NAGN-acetyl-beta-D-glucosaminidaseN-乙酰-β-D-氨基葡萄糖苷酶NF-κBnuclearfactor-κB核因子-κBPAEpost-antibioticeffect抗生素后效应ROSreactiveoxygenspecies活性氧SODsuperoxidedismutase超氧化物歧化酶SOPstandardoperatingprocedure标准化操作规程脱氧核苷酸末端转移酶介TUNELTdT-mediateddUTPNick-EndLabeling导的dUTP缺口末端原位标记法