降压饮对老年高血压病(1、2级)内皮素水平的影响及降压疗效观察

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1、提要目的：通过观察治疗前后血压及内皮四项值的变化，探讨内皮素在老年高血压病中的发病机制，观察降压饮临床疗效，为临床应用提供理论依据。方法：选取符合标准的60例老年高血压患者随机分为2组，治疗组30例，对照组30例。治疗组给予降压饮口服联合西药缬沙坦降压，对照组给予单药缬沙坦降压治疗。疗程8周。观察用药前后患者血压、内皮四项及症候积分的变化。结果：治疗组显效12例，有效14例，无效4例，总有效率87%。对照组显效8例，有效14例，无效8例，总有效率73%，组间比较有显著性差异（P<0.05）。两组血压治疗前后有显著性

2、差异（P<0.01），组间比较有显著性差异（P<0.01）。治疗组症候改善总有效率90.0%，对照组总有效率为66.7%，组间比较有显著性差异（P<0.05）。ET-1、PGF1a、TXB2、NO治疗前后两组有显著差异（P<0.01）,组间比较有显著性差异（P<0.05）。结论：降压饮能明显降低老年高血压患者血压，改善临床症状及内皮素等血管活性物质代谢，保护血管内皮。关键词降压饮；老年高血压；内皮素；疗效观察。JiangYaYinofendothelinlevelsandantihypertensiveeffect

3、sobservedinelderlyhypertensivepatients(leveloneandtwo)Speciality:Geriatrics，internalmedicineofTCMAuthor:SuiCunsenTutor:LiRuiAbstractObjective:Toobservebloodpressureandfourendothelinchangesbeforeandaftertreatment,investigatesendothelininelderlypatientswithhyper

4、tensioninthepathogenesisandobservetheclinicalefficacyofJiangYaYintoprovideatheoreticalbasisforclinicalapplication.Method:Selected60casesofelderlypatientswithhypertensionwererandomlydividedinto2groups,treatmentgroupof30cases,controlgroupof30cases.Treatmentgroup

5、wasgiventheJiangYaYinorallycombinedwithWesternmedicineValsartanof8weeks,thecontrolgroupreceivedsingle-drugValsartantreatmentof8weeks.Toobservedbeforeandaftertreatmentthepatient'sbloodpressure,fourendothelinandthesyndromescoreofchange.Results:Thetreatmentgrouph

6、ave12markedlycases,14effectivecases,4invalidcases,thetotalefficiencyof87%.Thecontrolgrouphave8markedlycases,14effectivecases,8invalidcases,thetotalefficiencyof73%,andbetweenthetwogroupshavesignificantdifference(P<0.05).Bloodpressureofthetwogroupshavesignifican

7、tdifferencebeforeandaftertreatment(P<0.01),andbetweenthetwogroupshavesignificantdifference(P<0.01).Totalefficiencyofsymptomimproveinthetreatmentgroupis90.0%,thecontrolgroupis66.7%,andbetweenthetwogroupshavesignificantdifference(P<0.05).Beforeandaftertreatmento

8、ftheET-1,PGF1a,TXB2andNO,thetwogroupshavesignificantdifferences(P<0.01),andbetweenthetwogroupshavesignificantdifference(P<0.05).Conclusion:TheJiangYaYincansignificantlylowerbloodpr