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1、第三军医大学硕士学位论文hHour小时minMinute分钟nmNanometer纳米IUGRIntrauterinegrowthretardation胎儿宫内生长受限ELISAEnzyme-linkedimmunosorbentassay酶联免疫吸附测定SEMscanningelectronmicroscope扫描电子显微镜SBPsystolicbloodpressure收缩压2第三军医大学硕士学位论文SyncytiotrophoblastMicrovillousMembraneCanInducepreeclampsia-likeChangesInMiceAbstractBackgroun
2、dandobjective:Pre-eclampsia(PE)isapregnancy-specificdisease.Theperformanceishypertension,proteinuriaandsoonafter20weeksofpregnancy,canbeaccompaniedtheheart,brain,kidney,liverandmultipleorgandysfunction,whichseverelythreatensmaternalandfetalhealth.ThemechanismofPEisstillunclearsothatthepredictionoft
3、hediseaseisquitedifficult.Inaddition,inearlystageofpregnancy,thereisnosubstantialprospectofpreciselyinterventionstopreventPEoneithertrophoblastinvasionnorembryo-maternalimmunetolerance.Thus,interventionorblockthepathophysiologicalprocessofPEismoresignificantinclinicaltreatmentafteritsonset.Clinical
4、manifestationsquicklydisappearaftertheplacentaisbeendelivered,whichindicatethattheplacentaanditspathophysiologicalfactorsmightbethemainlycauseofPE.Thirdtrimesterplacentalsurfaceentirelycoveredbysyncytiotrophoblas(ST).Syncytiotrophoblastmicrovillousmembrane(STBM)ismembranevesicle-likeparticlessheddi
5、ngintothematernalcirculationfromthemicrovilliofthesurfaceofST.StudieshaveshownthattheconcentrationofSTBMinperipheralcirculationinPEpatientsissignificantlyhigherthanthosewhoareexperiencinganormalpregnancy.AlargenumberofinvitrostudieshaveconfirmedSTBMiscloselyrelatedtotheincidenceofPE,butnotsomuchfor
6、invivostudies.Inaddition,innormalpregnancycases,distribution,metabolismortargetorgansofSTBMstillstayuncleartopresentknowledge.AndinPEcases,STBMmainpathogenicmechanismsanditsimpactonbodyfunctionsarealsosuspended.AndthebasiccompositionandkeypathogenicfactorsinthevivoleadtotheonsetofPEisunclear,itsmai
7、npathogenicmechanismsinvivoanditsmajororgans,functionalsystemisnotyetclear,anditsinvivodistribution,metaboliccharacteristics,themainroleoftargetorganisunknown.Itcouldprovidenewideasfortheclinicaltreatmentif
