高山红景天甙对血管性痴呆大鼠学习记忆与外周血ach含量的影响

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1、cerebrovascularinjuryandsalidrosid’Seffectiveinterventiononcognitiveimpairmentcombinedwithmorphologyindexandchangesofperipheralbloodacetylcholinelevel．Bythisresearch，itisexpectedtoprovideguidancereferenceonsalidrosidevasculardementiainthepreventiveprotectionandtreatment．M

2、ethods：44maleSDratswererandomlydividedintosham—operatedcontrolgroup，cerebralischemia／reperfusiongroup，preoperativeandpostoperativetreatmentgroup．IntraperitonealinjectionofSalidroside，12mg／mlofeachrat．ThroughtheTTC，HEandNisslstaining，wecanoperatemorphologicalobservation，th

3、roughtheMorriswatermazetoassessspatiallearningandmemoryabilityinratsanddeterminetheAChcontentinperipheralbloodinordertoexploremechanisms．ResuIts：1．MCAOmodelofcerebralischemiaThesuccessrateofmodelisnothigh，itsaveragesuccessrateis63．8％，oneofthemoccurredepilepticseizuresympt

4、oms，deathmostlyoccurredwithin24hsafterischemia．Thereisnodifferenceamongcerebralischemia／reperfusiongroup，thepreoperativetreatmentgroupandpostoperativetreatmentgroupinneurologyscore．Beforeandaftersurgery，wemonitoredtheweightoftherats，whichdecreasedafter24h，3dandweightpicke

5、dupinthe7d，RSGSpreoperativetreatmentgroupweighed237．43士9．02ginthe24h，significantlylowerthanthecontrolgroup(P<0．05)，whichweighed227．29+35．96gin3d．Therewasasignificantdifferencecomparedwiththecontrolgroupandcerebralischemiagroups(P<0．05)．ItindicatedRSGSplaysaroleinweightlos

6、s．Morphologicalobservationshowedthatthemiddlecerebralarterysuturemainlydamagecorticalandcaudateputamen．2．Assessmentofspatiallearningandmemoryability2．1Positioningnavigationtest：throughcomparingincubationperiodofratduring4day’Strainingtofindtheplatform，wefoundthattheincuba

7、tionperiodineachgroupissimilarin1-3d-trainedratsandtherewasnosignificantdifference．Butintheforthdayoftraining，incubationperiodof5cerebralI／Rgroupis37．69士12．95s，whileinsham·operatedcontrolgroupitiS17．35士16．OOs．therewasasignificantdifferencebetweenthetwogroups(P<0．05)．Howev

8、er，therewerenosignificantdifferencesamongsham—operatedcontrolgroup，preoperativetreatmentgroup(34