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ID:33381150
大小:2.51 MB
页数:37页
时间:2019-02-25
《补肾活血生骨法对激素性股骨头坏死家兔血清中no含量影响的实验研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、陕西中医学院硕士学位论文补肾活血生骨法对激素性股骨头坏死家兔血清中NO含量影响的实验研究姓名:史国号申请学位级别:硕士专业:中西医结合临床指导教师:刘德玉201204摘要目的:观察补肾活血生骨法(骨复生方)对激素性股骨头坏死家兔模型血清NO含量的影响,为补肾活血生骨法(骨复生方)对激素性股骨头坏死的治疗寻找出科学的理论依据,更好指导临床应用。·方法:采用贺西京家兔激素性股骨头坏死造模方法,将50只家兔分为5组,每组10只。A组(空白组)、B组(模型对照组)、C组(模型组+中药高剂量治疗组)、D组(模型组+中药中剂量治疗组),E组(模型组+中药低剂量
2、治疗组)适应性单笼喂养7天。每周两次肌肉注射醋酸泼尼松龙注射液8.Omg/(kg·次-1),连续注射8周共16次,空白对照组每四天一次肌注生理盐水2ml/(kg·次一1)。每次注射均在上午8点到11点之间,同时为预防感染,家兔每周肌注青霉素钠2-3次,每次8万单位,造模完成后给骨复生汤药灌胃四周后,测各组血清NO浓度将各组数值结果用统计学处理进行比较。结果:骨复生灌胃四周后组织学上可以观察到坏死区的骨质有修复的迹象。经统计学得出NO浓度结果表示,在模型组中中药高剂量的实验组灌胃后的血清NO浓度最高(P3、灌胃组N0浓度和坏死骨的修复较高剂量低(P4、生骨法骨复生方N0BUshenhuoxueshenggufaonthecontentofNOinserumofrabbitsWithsteroid—inducednecrosiSoffemoraIheadexperimentaIstudyoneffectAbstractPurpose:Bushenhuoxueshenggufa(Gufushengfang)observationontraditionalChinesemedicineprescriptiononserumNOcontentmodelinrabbitswithsteroid—induc5、ednecrosisofthefemoralhead,Bushenhuoxueshenggufa(Gufushengfang)Partiesonthetreatmentofsteroid—inducednecrosisofthefemoralheadtofindoutthetheoreticalbasisofscientific,clinicalapplicationofbetterguidance.Method:Hexijingsteroid—inducednecrosisoffemoralheadinrabbitsmodelmethod,50r6、abbitsaredividedinto5groups,eachgroupof10.Groupa(emptyset)b(modelcontrolgroup),groupC(modelgroup+traditionalChinesemedicinetreatedbyhighdosegroup),groupd(modelgroup+dose‘ofChinesemedicineinthetreatmentgroup),groupe(modelgroup+lowdoseofChinesemedicineinthetreatmentgroup)Adaptiv7、esinglecagesfeeding7days.Prednisoloneacetateinjection8.Omg/intramuscularinjectiontwiceaweek(kg·一1),injection8weeksatotalof16timesinarow,blankcontrolgrouponceeveryfourdaysofintramuscularinjectionofsalinesolution2ml/(kg·一1).Betweeneachinjectionat80’clockinthemorningtoIpoints,and8、atthesametimetopreventinfection,weeklyintramuscularpenicillin
3、灌胃组N0浓度和坏死骨的修复较高剂量低(P4、生骨法骨复生方N0BUshenhuoxueshenggufaonthecontentofNOinserumofrabbitsWithsteroid—inducednecrosiSoffemoraIheadexperimentaIstudyoneffectAbstractPurpose:Bushenhuoxueshenggufa(Gufushengfang)observationontraditionalChinesemedicineprescriptiononserumNOcontentmodelinrabbitswithsteroid—induc5、ednecrosisofthefemoralhead,Bushenhuoxueshenggufa(Gufushengfang)Partiesonthetreatmentofsteroid—inducednecrosisofthefemoralheadtofindoutthetheoreticalbasisofscientific,clinicalapplicationofbetterguidance.Method:Hexijingsteroid—inducednecrosisoffemoralheadinrabbitsmodelmethod,50r6、abbitsaredividedinto5groups,eachgroupof10.Groupa(emptyset)b(modelcontrolgroup),groupC(modelgroup+traditionalChinesemedicinetreatedbyhighdosegroup),groupd(modelgroup+dose‘ofChinesemedicineinthetreatmentgroup),groupe(modelgroup+lowdoseofChinesemedicineinthetreatmentgroup)Adaptiv7、esinglecagesfeeding7days.Prednisoloneacetateinjection8.Omg/intramuscularinjectiontwiceaweek(kg·一1),injection8weeksatotalof16timesinarow,blankcontrolgrouponceeveryfourdaysofintramuscularinjectionofsalinesolution2ml/(kg·一1).Betweeneachinjectionat80’clockinthemorningtoIpoints,and8、atthesametimetopreventinfection,weeklyintramuscularpenicillin
4、生骨法骨复生方N0BUshenhuoxueshenggufaonthecontentofNOinserumofrabbitsWithsteroid—inducednecrosiSoffemoraIheadexperimentaIstudyoneffectAbstractPurpose:Bushenhuoxueshenggufa(Gufushengfang)observationontraditionalChinesemedicineprescriptiononserumNOcontentmodelinrabbitswithsteroid—induc
5、ednecrosisofthefemoralhead,Bushenhuoxueshenggufa(Gufushengfang)Partiesonthetreatmentofsteroid—inducednecrosisofthefemoralheadtofindoutthetheoreticalbasisofscientific,clinicalapplicationofbetterguidance.Method:Hexijingsteroid—inducednecrosisoffemoralheadinrabbitsmodelmethod,50r
6、abbitsaredividedinto5groups,eachgroupof10.Groupa(emptyset)b(modelcontrolgroup),groupC(modelgroup+traditionalChinesemedicinetreatedbyhighdosegroup),groupd(modelgroup+dose‘ofChinesemedicineinthetreatmentgroup),groupe(modelgroup+lowdoseofChinesemedicineinthetreatmentgroup)Adaptiv
7、esinglecagesfeeding7days.Prednisoloneacetateinjection8.Omg/intramuscularinjectiontwiceaweek(kg·一1),injection8weeksatotalof16timesinarow,blankcontrolgrouponceeveryfourdaysofintramuscularinjectionofsalinesolution2ml/(kg·一1).Betweeneachinjectionat80’clockinthemorningtoIpoints,and
8、atthesametimetopreventinfection,weeklyintramuscularpenicillin
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