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ID:27292107
大小:309.00 KB
页数:44页
时间:2018-12-02
《活血补肾方治疗激素性股骨头坏死临床与相关实验的研究硕士论文》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、ClinicalandExperimentalStudyontheTherapyofSteroid-inducedAvascularNecrosisoftheFemoralHeadbyHuoXueBuShenFangSpeciality:OrthopaedicicsofTCMAuthor:GuoYaTutor:ProfessorZhangShihuaAbstractObjective:TostudythecurativeeffectofHuoXueBuSenFangintreatingsteroid-inducedavascularn
2、ecrosisofthefemoralhead(SANFH)andtoinvestigateitspossiblemechanism.Methods:Intheclinicalstudy,HuoXueBuShenFangwasusedin24casesofSANFHasthetreatedgroupcomparedwith21casestreatedbyXianLingGuBaoCapsuleforcurativeeffectobservation.Thedifferenceoncurerate,clinicalsymptoms,la
3、boratoryexaminationsbetweenthetwogroupswereobserved.Intheexperimentalstudy,24NewZealandrabbitswererandomlydividedinto4groups:normalgroup,modelgroup,controlgroupandtreatedgroup.TherabbitsincontrolgroupweretreatedwithXianLingGuBaoCapsuleandHuoXueBuShenFangwasusedintreated
4、group.8weekslater,todeterminethecontentofBoneglaprotein(BGP)、Hemorheology.Results:Intheclinicalstudy,therewasquitedifferenceincomparisonwithpretreatmentandpost-treatmentintreatedgroupeandcontrastivegroupeandtheeffectwasbetterintreatedgroupethancontrastivegroupe.Andthere
5、sultsshowedthatHuoXueBuSenFangcaneffectivelyimprovethesymptomsofSANFH.Theexperimentalstudyshowedinthemodelgroupthenecrosisoffemoralheadwasobvious,thecontentofBGPinplasmawasapparentlylower,thecontentsofhemorheologywerehigher.Alltheindiceshadobviouschangesinthecontrolgrou
6、pandthetreatedgroup.Thechangesofaboveindiceshadsignificantdifferenceinthetreatedgroupandcontrolgroup.Conclusion:Throughtheclinicalandexperimentalstudy,thecurativeeffectofHuoXueBuShenFangofthetreatedgroupisbetterthanthatofthecontrastivegroup.Themechanismmightberelatedwit
7、hitsactionsofmeliorationofhemodynamicsandmircocirculation,amelioratingthedisturbanceofmetabolismoffattiness,regulatingmetabolismofcalciumandphosphor,acceleratingthegrowthofchickenembryoincuvette.KeywordsHuoXueBuSenFang;Steroid-inducedAvascularNecrosisofFemoralHead;Clin
8、icalstudy;Experimentalstudy目录引言.............................................................................
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