不同麻醉深度丙泊酚对犬脑不同区域谷氨酸的影响

《不同麻醉深度丙泊酚对犬脑不同区域谷氨酸的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、ABSTRACTneuronaldeath．TheeffectsofpropofolonGLU弱follow：inhibitionofpresynapticactionpotentialpropagation,inhibitionofpresynapticreleasingforGLU，promotingthereuptakeofGLU，blockingGLUreceptorsofthepostsynapticmembrane．AstheanatomicalSlnlCtureanddistributionofCNShasacertainspecif

2、icity,theeflbctofanestheticsareselective．Thetargetactionofpropofolisinhypothalamus，butwedon’tknowwherethebullseyeis．Inthisstudy,thehypothalamusaredissectedtoobservetheeffectofpropofolonGLUindifferentcerebralregionsindogs．Theresearchofcerebraluptakeofpropofolusuallybasesonmassb

3、alanceprinciples．Duetothelimitationofexperimentalmethodsandtheparticularityofbrainructionindifferentbrainregions，theconcentrationsofpropofolatitssiteofactioninthebrainCan’tbeaccuratelycountedandthecharacterofregionalcerebraldistributionofpropofolcan’tberevealedbythismethod．Toi

4、mprovetheresearchofcerebraluptake，theconcentrationsofpropofolindifferentcerebralregionsmustbedetecteddirectlybyanatomy．ThemethodsofHPLC·UCCandetecttheuptakeanddistributionindifferentregionsundertheconditionofdifferentanesthesiadepth．Ourpreviousstudyfoundthattheuptakeanddistrib

5、utionindifferentregionsweredifferentatdifferentanesthesiadepth：propofolWasinjectedwithabolus，thepropofolconcentrationwerehighestinhypothalamusandbrainstemandlowestinhippocampusinlightanesthesia．Howeverindeepanesthesia,highestinthalamusandlowestinhippocampus．Theotherstudyshowed

6、thatplasmapropofolconcentrationsintheinternalcarotidarteryandinternaljugularveinreachequilibriumandpropofolWasdistributedevenlyexceptthedorsalthalamuscontaningahigherconcentrationat30rainofpropofolconstantinfusion70mg／(kg‘h)，propofolWasdistributedalmostevenlyamongregionalcereb

7、raltissuesat50minindogs．Theeffectofpropofolatdifferentanesthesiadepthonexcitoryorinhibitoryneurotransmitterindifferentcerebralregionsisstillunk_rlowlLTheaimofthisstudyistoinvestigatethee脏CtofpropofolonGLUindifferentregions(dorsalthalamus,epithalamns，metathalamus，hypothalamus，s

8、ubthalamus,fi'ontallobe，parietallobe，temporallobe，occipitallo