异丙酚不同麻醉深度下犬脑的摄取和分布

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1、硕士学位论文结论1．异丙酚不同剂量单次静脉注射，达到不同的麻醉深度时，颈内动脉和颈内静脉血浆异丙酚浓度差异显著，脑摄取仍在进行中。2．单次静脉注射达到不同的麻醉深度即刻，不同脑区异丙酚的摄取量不同：浅麻醉状态时桥脑异丙酚浓度最高，深麻醉状态时丘脑最高；海马均最低。关键词二异丙酚静脉麻醉脑摄取犬V硕士学位论文TheCerebralUptakeandRegionalDistributionofPropofolUnderDifferentDepthofAnesthesiainDogsName：Liuchang-·taoSupervi

2、sor：Linchun-shuiABSTRACTPropofolisarelativelynewintravenousanestheticandhasbeenwidelyusedingeneralanesthesiainductionandmaintenance．Recently,itispopularlyusedasasedativeagentintheintensivecareunit．Asweknow,brainistheeffectiveorganofintravenousanesthetics，theresearch

3、ofcerebealuptakeanddistributionisfavourabletoexplorethemechanismofgeneralanesthesia．In1988，Uptonputforwardtheconceptofcerebraluptakeandthefundamentalresearchmethodofmassbalancingprinciples．Theresearchaboutcerebraluptakeofpropofolusuallybasesonthemassbalanceprinciple

4、s．BymeasuringthepropofolconcentrationsinartelialandVenOusbloodofcerebralcirculation,wecancalculatethecerebralconcentrationsandevaluatethecerebraluptakeofpropof01．Basedonthemassbalancingprinciple，$ornescholarshadintroducedtheresearchofthecerebraluptakeofpropofolinthe

5、late-1990s．Thebasicgoalistoexploretheruleofpharmacokineticsandpharmacodynamicsofpropofol，improveandrenewexistedmethodofpropofolintravenousanesthesia．Themainresearchtechniqueistomeasurethepropofolconcentrationofarterybloodandthevenousbloodusinghigh-pressureliquidchro

6、matograph(HPLC)andtoevaluatethecerebraluptakeofpropofolbycalculatingtheareasundertheconcentration-timeCUlNesenteringandleavingthebrain．However,thecharacterofregionaldistributionofpropofolinthebraincannotberevealedyetbythismethod．Toimprovetheresearchmethodofcerebralu

7、ptake，thepropofolconcentrationsindifferentpartsofthebrainmustbedetecteddirectlybyanatomy．ShyrandLarssonhadcompa同thepropofoldistributioninthemousebraintissuesrespectively,thepropofolconcentrationswereme娜edbyhigh-pressureliquidchromatographyultra-violaspectroscopy(HPL

8、C-uv)method．111eydiscoveredthatthemidbrainwasdifferenttotheotherbrainfunctionareainintakingthemedicine．Itmaybeinjectedfactor,brainuptakeco