不同麻醉深度丙泊酚对犬脑不同区域γ氨基丁酸的影响

《不同麻醉深度丙泊酚对犬脑不同区域γ氨基丁酸的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、ABSTRACTpropofolinhibitedthereleaseofGABA．YaoShang-longfoundthatclinicallyappropriateconcentrationsofpropofolenhancedtheeffectofchlorideionuptakecausedbyGABAandGABAAreceptoragonists(muscim01)inratcorticalbrainslices，indicatingthatpropofolpromotedGABAandGABAAagonistmedi

2、atedchloridechannelactivity．BesidesitwaslikelytoaffecttheGABAAreceptor,viareducingtheGABAAreceptorchannelinactivationandslowingdownthedesensitizationprocess，resultingintheinhibitorypostsynapticpotential(IPSP)recessiondelay．’Theresearchaboutcerebraluptakeofpropofolusual

3、lybasesonthemassbalanceprinciples．Bymeasuringthepropofolconcentrationsinarterialandvenousbloodofcerebralcirculation,wecancalculatethecerebralconcentrationsandevaluatethecerebraluptakeofpropof01．Ourpreviousstudyfoundthatpropofoldistributionindifferentbraintissuesindogsw

4、agdifferent：ThepropofolconcentrationWashighestintheponsinlightanesthesiagroup，andWaghigherestinthehypothalamus，lowestinthehippocampusindeepanesthesiagroup．Theotherstudiesshowedthatplasmapropofolconcentrationsintheinternalcarotidarteryandinternaljugularveinreachedequili

5、briumandpropofolWagdistributedevenlyexceptthedorsalthalamuscontaningahigherconcentrationat30minofpropofolconstantinfusion70mg．kg-1．h．1，propofolWagdistributedalmostevenlyamongregionalcerebraltissuesat50minindogs．Theeffectofpropofolatdifferentanesthesiadepthoninhibitoryo

6、rexcitoryneurotransmitterindifferentcerebralregionsisstillunknown．ThechiefaimofthisstudyistoinvestigatetheeffectofpropofolonGABAindifferentregions(dorsalthalamus，epithalamus，metathalamus，hypothalamus，subthalamus，frontallobe，parietallobe，temporallobe，occipitallobe，hippo

7、campus，cingulategyrus，cerebellum,midbrain，pons，medullaoblongata,andcervicalcord)硕士学位论文whencerebraluptakeanddistributionofpropofolreachequilibriumatdifferentanesthesiadepths．Materialandmethods1AnimalpreparationandgroupingTwelve12·18一month-oldhealthyhybriddogsweighing10—

8、12kgwererandomlydividedintolightanestheticgroup(Lgroup，n一：6)anddeepanestheticgroup(Dgroup，n=6)．Theexperimentwasschedu