不同方式的非血管化结构性骨移植对骨缺损修复的实验分析

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1、新骨生成，A、B、C三组间比较P<005，有统计意义：术后4周：各组骨缺损区新生骨生成量较两周时明显增多，PA-n<0．05，有统计学意义；Pc-B(005，有统计学意义：PA矿0．05无统计学意义。术后8周：A、B、C三组间比较P>005，无统计学意义。结论：非血管化结构性骨移植在治疗骨缺损时，按骨小粱或应力方向不同植骨，对骨缺损的早期愈合是有影响的，将移植骨骨小梁方向与成骨方向一致植入骨缺损区，在早期骨愈合方面，要优于垂直骨生长方向植骨。关键词：骨移植，骨小梁，再血管化Experimentalstudyofthedifferentformsofnon—vas

2、cularizedstructuralbonegraftonboneSummaryObjeet：Non-vasculafizedstructuralbonegraftinbonedefectsinthetargetregiontostressindifferentdirectinnsofthetrabecularboneorbonegraftingonbonehealingofthemicro—environmentalimpactanalysisprinciplesandmechanismsthatmayexist．Forfurtherstudythmtl曲t

3、hedeterminationoftheindicatorsofthemicroenvironmentofthebonegraftbonedefectsinthetargetarea，repairandreconstructionofbonedefectsofdifferentbonegraftfromthemicroscopicstructureandmolecularphysicsandchemistry．Toexplorenewideas，toprovideaoewmethodfortheclinicaltreatmentofthebonedefectsM

4、ethods：Thisstudyfirstestablishedbonedefectmodel，choosethesameorigin，4-6months，weight2．5—35kg38NewZealandwhiterabbits，maleorfemale，inthemiddleofthefemurosteotumy15mm(includingperiosteum),boneendsclosedcanal，miniplatefixationoffemoralbonewaxtomaintaintheboneends15mmspacing，theX—raytode

5、terminebonedefectsafter12weeksSelectNewZealandwhitetabbitsweremadeofbonedefectmodel38(reserved2)，whichwererandomlydividedintoA，B，Candthreegroups(n2I2)Earveininjectionof3％sodiumpentobarbitalanesthesia，andtotakeonthessmesideforautologouslilacbonegraftsource，andthelilaccutsizeequalto8go

6、ngthetrabecularboneorstressdirection．Removetheplatescrewwhichwereusedtoproductedthefemoraldefectmodel．andcleanupthefibroustissueofthebonedefect,scleroticbone，recanalizatlonofthemedullarycav时，reset，online，缸edbymini—platescrew．GroupAplantlilacinfemoraldefectwithfemurstress(bonetrabecul

7、ae)inthesamedirection；GroupBplantinglilacblockinthedirectionthatperpendiculartotheexplantsoffemoralstress(trabecularbone)；GroupCrandomlyimplantedinthefemoraldefectarea．Usehomemadesplintfor2weeksaftertheoperation．Thendetectedatthe2nd，3“，4thweek,Eachtimeineachgroupwecollect4rabbits，det

8、ectiontheind