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ID:33089321
大小:5.81 MB
页数:56页
时间:2019-02-20
《不同方式的非血管化结构性骨移植对骨缺损修复的实验分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、新骨生成,A、B、C三组间比较P<005,有统计意义:术后4周:各组骨缺损区新生骨生成量较两周时明显增多,PA-n<0.05,有统计学意义;Pc-B(005,有统计学意义:PA矿0.05无统计学意义。术后8周:A、B、C三组间比较P>005,无统计学意义。结论:非血管化结构性骨移植在治疗骨缺损时,按骨小粱或应力方向不同植骨,对骨缺损的早期愈合是有影响的,将移植骨骨小梁方向与成骨方向一致植入骨缺损区,在早期骨愈合方面,要优于垂直骨生长方向植骨。关键词:骨移植,骨小梁,再血管化Experimentalstudyofthedifferentformsofnon—vas
2、cularizedstructuralbonegraftonboneSummaryObjeet:Non-vasculafizedstructuralbonegraftinbonedefectsinthetargetregiontostressindifferentdirectinnsofthetrabecularboneorbonegraftingonbonehealingofthemicro—environmentalimpactanalysisprinciplesandmechanismsthatmayexist.Forfurtherstudythmtl曲t
3、hedeterminationoftheindicatorsofthemicroenvironmentofthebonegraftbonedefectsinthetargetarea,repairandreconstructionofbonedefectsofdifferentbonegraftfromthemicroscopicstructureandmolecularphysicsandchemistry.Toexplorenewideas,toprovideaoewmethodfortheclinicaltreatmentofthebonedefectsM
4、ethods:Thisstudyfirstestablishedbonedefectmodel,choosethesameorigin,4-6months,weight2.5—35kg38NewZealandwhiterabbits,maleorfemale,inthemiddleofthefemurosteotumy15mm(includingperiosteum),boneendsclosedcanal,miniplatefixationoffemoralbonewaxtomaintaintheboneends15mmspacing,theX—raytode
5、terminebonedefectsafter12weeksSelectNewZealandwhitetabbitsweremadeofbonedefectmodel38(reserved2),whichwererandomlydividedintoA,B,Candthreegroups(n2I2)Earveininjectionof3%sodiumpentobarbitalanesthesia,andtotakeonthessmesideforautologouslilacbonegraftsource,andthelilaccutsizeequalto8go
6、ngthetrabecularboneorstressdirection.Removetheplatescrewwhichwereusedtoproductedthefemoraldefectmodel.andcleanupthefibroustissueofthebonedefect,scleroticbone,recanalizatlonofthemedullarycav时,reset,online,缸edbymini—platescrew.GroupAplantlilacinfemoraldefectwithfemurstress(bonetrabecul
7、ae)inthesamedirection;GroupBplantinglilacblockinthedirectionthatperpendiculartotheexplantsoffemoralstress(trabecularbone);GroupCrandomlyimplantedinthefemoraldefectarea.Usehomemadesplintfor2weeksaftertheoperation.Thendetectedatthe2nd,3“,4thweek,Eachtimeineachgroupwecollect4rabbits,det
8、ectiontheind
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