供体凋亡细胞输注诱导大鼠胰岛移植免疫耐受的分析

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1、TheStudyonImmunologicalToleranceofRatIsletsTransplantationInducedbyTransfusionofDonorApoptoticCellsBackgroundName：ZhangZhenSupervisor：Prof．CaiDehongABSTRACTIsletstransplantationtore．establishthesecretionsystemofinsullinhasbeenconsideredasamostpromisingtreatmenttoc

2、urediabetesmellitus．EspeciallytheSUCCESSofEdmontonProtocolin2000，hasdemonstratedthegreatprogresswhichhasbeenmadeintheterritoryofisletstransplantation，andaccordinglyexploitedanextensiveapplicationperspectiveofisletstransplantationtocopewithtypeldiabetes．However,tra

3、nsplantationrejectionandthepotentialriskcomingwiththeapplicationofimmunosuppressiveagentsarestilltheobstaclesunabletoovercomecompletely．Nowitisgenerallythoughtthatthekeytosolvetherejectionofallograftsistoinducetherecipient’Simmunetolerancetothegraftsfromthedonor．T

4、houghtherealesomanymeanstoinducethetolerance，noneofthemcanachievethecompletepermanentspecifictolerance．Apoptosisisakindofphysiologicalorpathologicalphenomenongenerallyexistinginthebiosystem，andplaysanimportantroleinmaintainingthebalanceandstabilizationofthehost’Si

5、mmunestate．Apoptotiecellscansecretelipidichaemostaticfactors，andpresent‘'eat—me’’signalsonthesurfacetoattractedthephagocytetoremovethemselves；atthesametime，antigent’presentingcells(monocytesandmacrophages，etc)CansecretemanyinhibitiveimmunefactorssuchasTGF-p、PGE2、I

6、L-10etc，afterthephagocytosis．Allofthesecreatamicroenvironmentforantigenrecognitionandinducetherelatedlyrnphocytes’ABSTRACTtolerancetoapoptoticantigenratherthantheinflammatoryresponse．Onthesegrounds，Sunetalproposedtomakeuseofthetransfusionofapoptoticcellstoinduceth

7、edonor’Sspecifictolerance．OurworkgrouphasdemonstratedthatapoptoticcellscanmakeaninhibitiveeffectontheproliferationofTlymphocytesinvitro，and⋯、researchershavereportedthattransfusionofapoptoticcellsCallnotablyprolongthesurvivaltimeofratallograflsafterthehearttranspla

8、ntationorlivertransplantation．SoweplantoinducetheaUogenicisletstransplantationtoleranceindiabeticSDratbypre-transfusionofapoptoticcellstoinvestigatethem