大黄素甲醚对大鼠脑缺血预处理后缺血再灌注损伤保护作用的分析

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1、英文摘要———_————————————————●————————_———————_—●—————_——————-——————————一一StudyoftheprotectiveeffectsofPhysciononcrerbralischemia—reperfusioninjuryinratsafterbrainischemicpreconditioningABSTRACTObjective：IschemiccerebrovasculardiseaseisakindofconTtnondiseaseinclinicalpractice，whichhasahighermorbidityandu

2、nfavorableprognosis．Sorecoveringthebloodsupplyofthecerebralintimeisregardedasaimportanttreatmentforischemiccerebrovasculardisease．However,cerebralinjurycausedbyischemia—reperfusioninjurywouldbemoreseriousthanischemicinjuryitself．Recently,itisdiscoveredthatbriefischemicpreconditioninginadvancecanredu

3、cethecerebralinjurycausedbyischemia-reputationthroughinducingischemiatoleration．IthasbeenreportedthattheinflammatoryreactionmayhaveimportantmeaningincerebralIRandischemictolerance．Inhibitinginflammatoryreactioncanreducethecerebralischemia—reperfusioninjury．PhyscionisakindoftraditionalChinesemedicine

4、whichcanDasstheblood-brainbarrierandhasstronganti—inflammationaction．SomestudiesshowedPhyscioncanreduceischemia．reperfusioninjury,buttheeffectoncerebralischemictolerancehasn’tbeenreported．Theratmodeloffocalcerebralischemiawascreatedbymiddlecerebralarteryocclusion(MCAO)afterZea—longabymakingsomemodif

5、ication．By———————————d———————————————_————————————————————一——————————————————————————————一一5荚文摘要comparingtheneurologicaldeficitsscores，thevolumeofinfarctionandthelevelofNSEinseramweredetectedtoobservetheprotectiveeffectsofcerebralischemicpreconditioningoncerebralischemia—reperfusion(IR)injury．Thelev

6、elofinterleukin一113(IL一1D)aswellastumorenecrosisfactor-Ⅱ(TNF-a)wasobservedwithradio—immunoassay．ThepurposeofthisstudyistoexploretheeffectsofPhysciononpreventingcerebralischemicinjury．Methods：120healthymaleSDadultratswereselected，andweredividedinto4groupsrandomly：(1)GroupA：shamgroup(SS+SS)whichreceiv

7、edshamsurgerytwiceandthenumberwas40．Intheshamgroup，theratsonlyexposedthecommoncarotidartery,intemalcarotidarteryandexternalcarotidarterywithoutblockinguptheMCA；(2)GroupB：cerebralischemia-reperfusiongr