降逆解郁汤治疗肝胃不和型胆汁反流性胃炎的临床研究

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1、提要目的：观察降逆解郁汤治疗胆汁反流性胃炎（Bilerefluxgastritis，BRG)，中医辨证为肝胃不和型的临床疗效，并且从理论和临床研究两个方面探讨降逆解郁汤治疗肝胃不和型BRG的机制。方法：临床选择符合纳入标准的BRG患者60例，随机分为两组，实验组（30例）给予降逆解郁汤，对照组（30例）给予枸橼酸莫沙必利分散片和雷贝拉唑钠肠溶片，两组均以4周为一疗程。观察两组的临床疗效，并对治愈患者随访6个月，观察远期疗效。结果：临床研究显示，实验组中医证候疗效、胃镜疗效及远期抗复发疗效等均优于对照组（P＜0.05或P＜0.01）。实验组能明

2、显改善胃脘胀满或疼痛，嘈杂不适，吞酸、嗳气、恶心、口苦、不欲食、情绪抑郁、善太息等症状，其疗效优于对照组（P＜0.05或P＜0.01）。两组治疗期间均未发生不良反应。结论：降逆解郁汤是治疗肝胃不和型BRG的有效方剂，其机理可能与促胃肠动力、抑酸、改善黏膜血流量、增强黏膜屏障、抗炎等有关，经大量临床资料调查，无明显不良反应，值得进一步推广应用。关键词降逆解郁汤；胆汁反流性胃炎(Bilerefluxgastritis，BRG)；肝胃不和；临床研究ClinicalStudyofTreatingBilerefluxgastritisofsyndrom

3、eofincoordinationbetweenliverandstomachwithJiang-ni-jie-yu-tangSpecialty：GastroenterologyInternalMedicineofTCM.Author：ZhangChunlanTutor：ProfessorLuGuangchaoAbstractObjective:ToobservetheeffectofJiangnijieyutang(JNJYT)onBilerefluxgastritis(BRG)，andexplorethemechanismofit.Met

4、hods:60patientswithBRGweredividedintotwogroupsatrandom:thetreatmentgroupandthecontrolgroup.ThetreatmentonewasgivenJNJYT，andthecontrolonewasgivenMosaprideCitrateDispersibleTabletsandRayBellaofintestinalsodiumtablets.Fourweeksweresetasacourseoftreatment.Theclinicaleffectsofea

5、chgroupwereobservedduringthecourseandthefollow-upsurveyof6months.Results:TheeffectiveofsyndromeofTCM、enteroscopyobservingofthetreatmentgrouparesuperiortothatofthecontrolgroup(P＜0.01orP＜0.05).JNJYTcanobviouslyimprovethesymptomssuchasStomachburningpaindiscomfortordullpain，noi

6、sy，fullness、mouthpain、anorexia、nausea、irritablemoodetc.thanMosaprideCitrateDispersibleTabletsandRayBellaofintestinalsodiumtablets(P＜0.01orP＜0.05).Conclusions:JNJYTisinforceinthetreatmentofBRG.Themechanismofthistherapymaybeimmediatelyinvolvedinpromotinggastrointestinalmotili

7、ty、acidsuppression、toimprovemucosalbloodflow、toenhancethemucosalbarrier,anti-inflammatoryetc.Keywords：Jiang-ni-jie-yu-tang(JNJYT)；Bilerefluxgastritis(BRG)；syndromeofincoordinationbetweenliverandstomach；Clinicalstudy.目录引言......................................................

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