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ID:32914013
大小:1.90 MB
页数:34页
时间:2019-02-17
《过敏性哮喘患儿ccl18相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、青岛大学硕士学位论文过敏性哮喘患儿CCL18相关性研究姓名:王健申请学位级别:硕士专业:免疫学指导教师:高美华20120529中文摘要过敏性哮喘患儿CCLl8相关性研究摘要目的趋化因子是能使细胞发生趋化运动的小分子细胞因子,对嗜中性粒细胞.淋巴细胞.单核细胞等多种细胞均有趋化作用。CCLl8是自发表达于肺的细胞因子,在一些肺疾病中表达增高,引起众多研究者关注。近年来趋化因子在过敏性疾病中的作用日益受到重视。CCLl8由TH2型细胞因子诱导产生,且研究表明过敏性疾病的的免疫学基础以TH2型应答为主导。但CCLl8在哮喘中的应用少有报道。本文对此问题进行分析探讨,并收集患者血样进行分析。
2、方法1.收集过敏性哮喘患儿和非过敏者的PBMC和BAL,研究过敏性哮喘者和非过敏者B^L中CCLl8水平的表达和过敏原DerPl对PBMC表达CCLl8的影响。2.选取52例哮喘发作患儿,按病情轻重分为轻.中.重三组,另选10例健康儿童为对照组。用ELISA法研究血清中CCLl8在其治疗前后的变化情况。结论1.DerPl显著增高了CCLl8在哮喘患儿患者PBMC的表达:哮喘患儿患者BALF中CELl8水平增高。2.过敏性哮喘息儿中度组和重度组的CCLl8水平显著高于对照组(P3、相关。中度组和重度组治疗后显著下降(P4、inlungs,anditexpressinhighlevelsinsomelungdiseases.Thisaroseattentionofmanyresearchers.Inresentyearschemokinswerepaidmoreattentionsbyresearchersinallergicdisease.TheproductionofCCL18isinducedbytheTh2.typecytokins.TheinmunologicalbasisofallergicdiseasesisorientedbyTh2-typeresponse.Buttherearefew5、reportsofCCL18inallergicathema.Nowwecollectedandanalyzedthebloodofpatientsinordertoinvestigatethesubject.Methods1.PBMCandBALwerecollectedinallergicathemaandnonallergicathemapatients,inordertostudytheexpressingofCLL18inBALandPBMCwhichinflunesedbyDerp1.2.52patientswithacuteallergicathemaweredivid6、edinto3groupswithseverity.10normalsubjectsworkedascontrolandCCL18leveloftheserumweremeasuredrespectivelybyELISA.WestudyCCLI8changesinpatientsbeforeandaftertreatment.Conclusion1.DerplsignificantlyincreasedtheCCL18expressioninPBMCofchildrenpatients;AndchildrenpatientshaveincreasedlevelsofCCLI8inB7、ALF2.CCL18levelsinmoderateandseveregrouparehigherthanthatincontrolgroup(P
3、相关。中度组和重度组治疗后显著下降(P4、inlungs,anditexpressinhighlevelsinsomelungdiseases.Thisaroseattentionofmanyresearchers.Inresentyearschemokinswerepaidmoreattentionsbyresearchersinallergicdisease.TheproductionofCCL18isinducedbytheTh2.typecytokins.TheinmunologicalbasisofallergicdiseasesisorientedbyTh2-typeresponse.Buttherearefew5、reportsofCCL18inallergicathema.Nowwecollectedandanalyzedthebloodofpatientsinordertoinvestigatethesubject.Methods1.PBMCandBALwerecollectedinallergicathemaandnonallergicathemapatients,inordertostudytheexpressingofCLL18inBALandPBMCwhichinflunesedbyDerp1.2.52patientswithacuteallergicathemaweredivid6、edinto3groupswithseverity.10normalsubjectsworkedascontrolandCCL18leveloftheserumweremeasuredrespectivelybyELISA.WestudyCCLI8changesinpatientsbeforeandaftertreatment.Conclusion1.DerplsignificantlyincreasedtheCCL18expressioninPBMCofchildrenpatients;AndchildrenpatientshaveincreasedlevelsofCCLI8inB7、ALF2.CCL18levelsinmoderateandseveregrouparehigherthanthatincontrolgroup(P
4、inlungs,anditexpressinhighlevelsinsomelungdiseases.Thisaroseattentionofmanyresearchers.Inresentyearschemokinswerepaidmoreattentionsbyresearchersinallergicdisease.TheproductionofCCL18isinducedbytheTh2.typecytokins.TheinmunologicalbasisofallergicdiseasesisorientedbyTh2-typeresponse.Buttherearefew
5、reportsofCCL18inallergicathema.Nowwecollectedandanalyzedthebloodofpatientsinordertoinvestigatethesubject.Methods1.PBMCandBALwerecollectedinallergicathemaandnonallergicathemapatients,inordertostudytheexpressingofCLL18inBALandPBMCwhichinflunesedbyDerp1.2.52patientswithacuteallergicathemaweredivid
6、edinto3groupswithseverity.10normalsubjectsworkedascontrolandCCL18leveloftheserumweremeasuredrespectivelybyELISA.WestudyCCLI8changesinpatientsbeforeandaftertreatment.Conclusion1.DerplsignificantlyincreasedtheCCL18expressioninPBMCofchildrenpatients;AndchildrenpatientshaveincreasedlevelsofCCLI8inB
7、ALF2.CCL18levelsinmoderateandseveregrouparehigherthanthatincontrolgroup(P
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