慢性粒细胞白血病基因分型的个体化研究及尼洛替尼临床疗效观察

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1、目录中英文缩写对照表...........................................................................................1中文摘要..............................................................................................................3英文摘要.........................................

2、.....................................................................5引言.......................................................................................................................8材料与方法一................................................................

3、....................................10结果一...................................................................................................................18讨论一.....................................................................................................

4、..............21材料与方法二.....................................................................................................24结果二...................................................................................................................25讨论二..............

5、.....................................................................................................27结论.......................................................................................................................29参考文献................................

6、..............................................................................30附录.......................................................................................................................33综述.........................................................

7、..............................................................35英文缩略词表﹙abbreviations﹚慢性粒细胞白血病chronicmyeloidleukemiaCML费城染色体philadelphiaPh断裂点丛集区breakpointclusterregionBCR伊马替尼imatinibIM酪氨酸激酶抑制剂tyrosinekinaseinhibitorTKIB细胞特异的莫洛尼白血B-cell-specificmoloneyleukemiaBMI1

8、病毒插入位点1virussite1蛋白酶3proteinase3PR3弹性蛋白酶elastaseELA2慢性期chronicphaseCP早慢性期earlychronicphaseECP晚慢性期latechronicphaseLCP加速期acceleratedphaseAP急变期blastcrisisBC血液学完全缓解comple