右美托咪定不同处理方式对大鼠局灶性脑缺血再灌注损伤的干预-研究

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1、万方数据四川医科大学硕士学位论文Dex2组二者之间NDS分值及BIVP比较无明显差异(P>O．05)。4、盐酸右美托咪定三种不同干预方式处理组组间比较，Dexl组和Dex3组NDS分值较Dex2组显著降低(PO．05)；Dexl组和Dex3组NDS分值及SOD活性比较无显著差异(P>O

2、．05)；Dexl组和Dex2组SOD活性比较无显著差异(P>O．05)。结论：1、在改良线栓法制作的大鼠右侧大脑中动脉阻闭再灌注模型上，三种不同干预方式的盐酸右美托咪定处理均能够减轻局灶性脑缺血再灌注损伤。2、盐酸右美托咪定预处理联合后处理能够产生效果更佳的脑缺血再灌注损伤保护作用。3、盐酸右美托咪定通过抑制过度氧化应激反应、减少过量氧自由基生成可能是其脑缺血再灌注损伤的保护作用机制之一。关键词：盐酸右美托咪定；脑缺血再灌注损伤；预处理；后处理万方数据EffectofDifferentTreatmentsofDexmedetomidineonFocalCerebral

3、Ischemia--ReperfusionInjuryinRatsAbstractObjectives：Accordingtotherightmiddlecerebralarteryocclusion．reperfusionmodelthatwasmadebyreformingLongamethod，tosimulatethepathophysiologicalprocessofacutecerebralischemiareperfusioninjuryinhumanbody．Investigatingtheeffectofdifferenttreatments(pre

4、conditioning，post—conditioningandpreconditioningunitedpost-conditioning)ofdexmedetomidinehydrochloride(Dex)onfocalcerebralischemia-reperfusioninjuryinrats．Byevaluatingthechangedifferenceofneurologicaldeficitscoresandbraininfarctvolumepercentageinratmodels，detectingsuperoxidedismutase(SOD

5、)activityandmalonaldehyde(MDA)contentinbraintissue，andmeasuringneuronspecificenolase(NSE)contentinserum．Fromtheentirety,neurologicaldeficitbehavioral，partialhistopathologyandmolecularleveltodiscussthedifferenteffectofDexonfocalcerebralischemia．reperfusioninjuryinrats，andtoinferthepossibl

6、emechanismofit．Thentoofferaclearandeffectivetherapeuticmethodandacertainreferencetothecerebralvasculardiseasepatientsandthecerebralischemiahigh-riskpatientsduringperioperativeperiod．Methods：40healthymaleSDrats，aged49—63days，weighing250—3009，wereusedin4万方数据四川医科大学硕士学位论文thisstudy．40ratswere

7、dividedinto5groupsrandomly：theshamoperationgroup(Sham)；thecerebralischemic—reperfusiongroup(I／R)；thedexmedetomidinehydrochloridepreconditioninggroup(Dex1)；thedexmedetomidinehydrochtoridepost—conditioninggroup(Dex2)andthedexmedetomidinehydrochloridepreconditioningunitedpos