支架置入术后晚期食管癌患者预后影响因素的cox回归分析

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1、维普资讯http://www.cqvip.com《癌症》ChineseJournalofCancer，2003，22(1)：91—9491·临床研究·支架置入术后晚期食管癌患者预后影响因素的Cox回归分析傅剑华，戎铁华，李小东，马国伟，胡吉吉，闵华庆CoxRegressionAnalysisofthePrognosticFactorsofUnresectableEsophagealCarcinomaafterStentingFuJian—Hua，RongTie—Hua，LiXiao—Dong，MaGuo—Wei，HuYi，MinHua

2、—Qin【ABSTRACT】BACKGROUND&OBJECTIVE：Therearemanyfactorsafecttheprognosisofthepatientswithunresectableesophagealcarcinomawhounderwentintubation，however，itisunclearwhichonesaremaincausessofar．Thisstudywasdesignedtoanalyzetheprognosticfactorsofunresectableesophagealcarcinom

3、aafterstentinginordertofindthereasonablemodalitiesofpalliativetherapy．METHODS：Consecutive1O2patientswithunresectableesophagealcarcinomawhowereeligibleforinclusioncriteriawereanalyzedafterstenting．Twelvefactorsincludinggender，age，tumorsite，tumorlength，stricturedegreeindi

4、ameter，pathologictype，gradeofcelldiferentiation，clinicaltumorstage(T，N，M)，pre—stentingtherapyandpost—stentingtherapy(radiotherapyand／orchemotherapy)wereusedforCoxregressionmodelanalysis．Thesurvivalratewascalculatedbylifetable．RESUL-TS：Thetechnicalsuccessrateofstentingwa

5、s98．3％．Thereweresignificantimprovementonthegradeofswallowingfunction(P=0．000)andqualityoflife(KPSscores，P=0．000)．Theincidencerateofcomplicationswas43．1％(44／102)Thesurvivalratesof3，6，9，12monthswere67．53％，40．59％，27．43％，and18．65％，respectively．TheresultsofCoxregressionshowe

6、dthatinvasiondegreeofprimarytumor(T，P=0．0410)anddistalmetastasis(M，P=0．006)werethestatisticallysignificantprognosticfactorsTheoddsratio(ORr)was1．750(95％CI，0．996—3．074)onTstageofprimarycarcinoma，ORMwas1．527(95％CI，1．126—2069)onMstage．TherewasnostatisticaIsignificanceinthe

7、survivalofthepatientsafectedbyradiotherapyand／orchemotherapyafterintubationCONCLUSION：TstageandMstagearethemajorprognosticfactorsafectingthesurvivalofpatientswithunresectableesophagealcarcinomaafterstenting．Thereisnobenefitforsurvivalofpatients中山大学肿瘤防治中心胸外科，treatedwithr

8、adiotherapyand／orchemotherapyafterintubation．广东广悄510060KEYWORDS：Esophagusneoplasms；Stenting；PrognosticfactorsC