不同剂量达肝素钠对择期经皮冠状动脉介入术后心肌损伤的影响

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1、荚文摘要—————————————————————————————————————————————————一EffectsDifferentDosesofDalteparinforAnticoagulationonMyocardialInjuryinPatientsUndergoingElectiVePercutaneousCoronaryInterVentionABSTRACTObiective：Corona巧he砒disease(CHD)isoneoftheusualdlseases1eadspeopletodeathwhoisoVer40years，whichls

2、morepreValencelnmen·Recently，percutaneouscorona巧intervention(PCI)isrecognizedaSoneo士efrectivetreatmenttoCHD．Themyocardialinju巧duringPCIisassociatedwithproceduralcomplicationssuchasincidentalsidebranchoccluslonandthrombusf．omlation．Therefore，anticoagulationisaVeD，lmpom呲stepdunngPCI．Genera

3、lly，un疔actionatedheparillisusedasthefirStcholceo士anticoagulation．However'thesensitivenessandmetabolismofUFHdifrerwithdifferentpatients，anditiseVenharderforustotest1tsph卸盯nacodyn锄icsandph剐1nacoldnetics．ManyprospectlVe，controUedclinicaltrialshadinvestigatedtheuseofLMⅥ1HVs．UFHinthetreatment

4、ofPCI．madeLMWHthefirstchoiceforanticoagulationduringPCI．PCItreatmentmightcauseelevationofbiochemicalmarkers(OTnI，MY0，CK-MB)incertainpatientsbecauseofmyocardialinjury，therefore，anticoagulant1spresentingtothesepatientsinordertoa11eViatetheinju巧causedbyPCIprocedure．Experimentwehaddoneshowed

5、nostat砸cslgnlncancebetweenLMWHanddaltep撕ndu打ngelectiVePCI，supportingtheuseo士dalt印眦nmelectivePCI．Thisresearchf．0cusesoninfluenceofusingdi行．erentdosesofdalteparinonmyocardial硼u巧inelectiVePCI，probingintotheoptimaldoseof呦t印arininthetreatmentofelectiVePCI．Methods：FromAugust2006t0December201O，

6、Atotalof294patientS(56．4±9．8years，female23．1％)withCHDunde玛oingelectiVePCIweredividedinto3l；roupsadministereddifrerentdosesofdaltepannVlaarteD，sheath：Group1(66patients，55．O±9．9years，female22．7％，administereddalteparin10000U)，Group2(39patients，57．2±9．3years，female35·9％，英文摘要administereddalte

7、parin5000U)andGroup3(189patients，56．8±9．8years，female20．6％，administereddalteparin120U／1鸥)．Baselinecharacteristics(age，gender，renalmnction，meannumberofstentsperpatient，preValenceofsmoking，diabetes，hypertension，highLDL—C)werematching．BeforethetreatmentofPCI，allthepatiemswer