化瘀通络中药对肝纤维化大鼠的防治作用及其对tgf-β1%2fsamd信号通路的影响

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1、英文摘要TraditionalChinesemedicineforactivafingbloodcirculationandeliminatingstasisofhepaticfibrosisratsanditseffectontheTGF—I吕l／SmadsignalingpathwaysABSTRACTObjective：Hepaticfibrosisisapathologyprocessthatliverdiffuseextracellularmatrixexcessivelydepositbecauseofvariouspathogenicfacto

2、rscausingabnormalintrahepaticconnectivetissuehyperplasia，itisalsothemajoraspectsofthedevelopmentofchronicliverdiseasetocirrhosis．Therefore，timelyblockingandreverseliverfibrosisisthekeytopreventcirrhosisandimprovetheprognosisofliverdisease，Avarietyofcytokinesandsignaltransductionpat

3、hwaysinvolvedinliverfibrosisdevelopmentprocess，transforminggrowthfactorbeta(transforminggrowthfactorbeta,TGF—beta)isakindofpolypeptideCanregulatecellgrowthandcelldifferentiation，itisthemostcriticalcytokinemediatedliverfibrosis．ItCanactivatehepaticstellatecells，activatedHSCfurthertr

4、ansformedintomyofibroblasts，expressinga—smoothmuscleactin(alpha—SMA)，ensynthesizeandsecreteECM．TGF—p1／Smadssignalpathwayisoneofthemostimportantregulatorymechanismofliverfibrosis，itisofgreatsignificancetotheformationofliverfibrosis．Theresearchersconductedamassofstudiesfortheliverfib

5、rosis，butblockingofliverfibrosisiSstilldifficultinclinical，recently,theoryoftraditionalChinesemedicineresearchandclinicalpracticeshaveprovedthat，usingtheChinesetraditionalmedicinetopreventtheliverfibrosisindicatesthecertainadvantageviamuti．pathwayandmuti—targetspotstointegrate，Chin

6、esetraditionalmedicineBiejiajianwan(BJJW)whichiSthemainmedicinefortreatingmother-of-malariacomesfromJinguiyaoluewrotebyZhangzhongiing，itpromotesthebloodcirculate，removingthebloodstasis，usingthegentlemethodandforce，replenishingqitOinvigoratethespleen．Demonstratedbyagreatnumberofexpe

7、riment，Biejiajianwan(BJJW)hasthefunctionforliverfibrosisandliver3英文摘要cirrhosis，ThisresearchwilltaketheCCL4methodforSDmousetoestablishtheliverfibrosismousemodel，Biejiajianwan(BJJW)，whichpromotethebloodcirculateandremovethebloodstasisisputinusetointerposefor也emodel．Observingthegenera

8、lsituationofexperimentanim