全反式维甲酸在肺癌细胞中的作用机制

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1、Abstractinspection，otherwisechooseapplicationspearmaninspection，andtestthecorrelationcoefficientwithsignificantinspection．Inspectionstandard口=0．05．Results：1．ObservinginMTT,for24h，48hand72h，intheATRAgroup，thetwodrugsjointedgroupsandeisplatingroup，tobeingcomparedthedifferencetot

2、henegativegroup，andfindthedifferencewasstatisticallysignificant(P<0．05)；Afterusingdrugsfor24h,betweenthedifferentconcentrationsofATI乙～groups，theinhibitoryratesincreasingwiththeconcentration(P

3、etweenthedifferentconcentrations0fATRAgroups，theinhibitoryratesincreasingwiththeconcentration(P0．DJ)；Afterusingdrugsfor72h，betweenthedifferentconcentrationsofATRAgroups

4、，theinhibitoryratesincreasingwiththeconcentration(P0．05)2．CalculateconcentrationofdrugsinthegroupstherelativecontentofPDCD5andTP53mRNA．Thedifferencebetweentherelativel

5、ynumericalcontentofPDCD5andTP53ineachgroupcontrasttogroupl，P<0．05，thedifferencewasstatisticallysignificant．Comparinggroupatogroupb，t=2．749,P=0．011<0．05，thedifferencewasstatisticallysignificant．DrawingstatisticalgraphsaboutdifferentgroupsofATRAandDDPtheroletherelativecontentofd

6、ataPDCD5TP53mRNAdistributiont0inA549cellsoflungcancer,andcalculateSpearmanco．elationcoefficient，r,=0．255,usingsignificantinspectionforcorrelationcoefficient，P<0．05,inspectionstandard口=0．05．Conclusion：ThegrowthoflungCanCel"cellsA549callbeinhibitedbyATRA，andithasbeenfoundtheinhi

7、bitoryeffectionoftheATRAdependentonconcentrationandtime．ThemoresuitableconcentrationofATRAtothetumoris10一mol／L．CombinatingATRAVIAbstractwithDDP,canmaketheinhibitoryeffectionstrongerthanthatwithsingledrug，andreducethesideeffectsthedrugscausedinthefurther．ATRAbeingusedsingleorco

8、mbinatedcallalSOinhibittheexpressionofthegenesrelatedtocellap