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1、安徽医科大学硕士学位论文TheprotectiveeffectofN-acetylcysteineonpneumoniamodelofsimulatedweightlessnessAbstractObjectiveInweightlessnessorsimulatedweightlessness,theimmunefunctionimpaired,andtheabilityofresistanceagainstinfectionreduced.N-acetylcysteine(NAC)iscommonlyusedasexpectorantdrugsc
2、linically,ontheotherhand,italsobeusedasimmuneregulation,inhibitionthespreadofthebacteriaandinflammation,andrestrainofthegenerationofbiofilm.Inthisstudy,weexploredtheabilityofresistancetotheinfectionofStreptococcuspneumoniaeofthebodyduringsimulatedweightlessness,whichbeingsetupt
3、hroughtailsuspension.Besidesthis,theprotectiveroleofN-acetylcysteinewasalsoobserved.Fromthese,maybewecanprovideatheoreticalbasisforthemedicineandprotectionofinfectionwhileinweightlessness,providethebasisforaerospaceMedicare.MethodsThesimulatedmicrogravityandinfectedanimalmodel:
4、HealthycleanmaleWistarrats(n=32),weight(270±20)g,randomlydividedinto4groups:GroupA(tailsuspension,infectionandNACgroup),GroupB(tailsuspension,NACandnoinfectiongroup),GroupC(tailsuspension,infectionandnoNACgroup),GroupD(tailsuspension,noinfectionandnoNACgroup.Theexperimentperiod
5、was9days.NACwerefedbyintragastricadministrationonthefirstday,whilesameamountofdistilledwaterwerefedincontrolgroup.Onthesecondday,themodelsofsimulatedweightlessnesswereduplicatedbytailsuspensionmethod(Eachratwashungbyitstailinacage,and30degreeswiththehorizontal).5安徽医科大学硕士学位论文The
6、ratswereintratrachealinstilledwith0.4mlsuspensionofstreptococcuspneumoniaeaftertail-suspensionfor3days.Atthesametime,no-infectiongroupswereintratrachealinstilledwith0.4mlsterilesaline.Attheendofexperiment,theratswerekilled.Theleukocytesandneutrophils,CD11bandDCFH-DAinthebloodwe
7、restudied.Thepathologyoflungtissuewerealsoobserved.Results:1.Thepathologicalchangesofratlung:IngroupC,obviouscongestionofthelungtissuecouldbeobserved.Someofalveolusgotfusion,alveolarseptumgotsick,lung’ssmallveinsandcapillariesdilatedandcongestion.Largenumberofneutrophilsandlymp
8、hocytesinfiltratedintheinterstitial,foamcellsfloodedin
