cpgodn对哮喘小鼠肺组织共刺激分子b7和cd40表达的影响

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1、温州医学院硕士学位论文groupCandgroupD(1．26士0．21)and(1．25士0．45)respectivelyweresignificantlyhigherthanB(P<0．01)；TherewerenodifferencebetweengroupCandgroupD(P>0．05)．(5)TheresultsoflungCDS0andCD40mRNAexpressionbyinmunohistochemistryexamination：Immunohistochemistryshowedthatthepredominantcellsinlungtis

2、suesthatexpressedCD80andCD40wereepithelialcellsandtheinflammatorycellsofbronchialsurroundly．theproteinexpressionofCD80ingroupB(0．29a：0．04)wassignificantlyhigherthanthoseingroupA(O．18士0．03(P

3、TherewcrcnodifferencebetweengroupCandgroupD(p>O．05)。theproteinexpressionofCD40inbronchusepithelialcellofgroupB(0．22．-L0．03)wassignifcantlyhigherthanthoseingroupA(O．17士0．07(P<0．05或P<0．01)；thoseofgroupC(O．15士O．04)andgroupD(0．15士0．05)weremuchdecreasedcomparedwithgroupB(P<0．01)；Therewerenodi

4、fferencebetweengroupCandgroupD(P>0．05)．(6)Correlativeanalysis：(1)TherewerepositivecorrelationsbetweenCD80andtheproteinexpressionsofCD40(representedbymeanopticaldensity，MOD)inlungtissues(严0．33，P<0。05，n=40)；(2)ThereweresignificantlypositivecorrelationsbetweenExpressionofCD86mRNAandCD40mRNA

5、(r=0．52，P

6、andCD40、Fc￡R1werestronglyexpressedinthemiceacuteasthmamodelsensitizedbyOVA，butFcl,RIIbwassignificantlydecreased，itshowsthatCostimulatorymoleculesandFceRI，FcTRIIbplayanimportantroleinasthma．(2)CpGODNlowercostimulatorymoleculesB7、CD40andFceRIexpressioninthelungtissue,andincreaseFcTRIIbexpr

7、essionandimproveairwayinflammation，induceimmunetolerance．(3)DexamethasonelowercostimulatorymoleculesB7、CD40andFceRIexpressioninthelungtissue，andincreaseFetRIIbexpression，improveairwayinflammation，induceimmunetolerance．KEYWORDS：Asthma；mice；CpGODN；bronchialasthma；costimulat