218例小细胞肺癌患者预后多因素分析

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1、大连医科大学硕士学位论文Analysisof218casesofmultiplefactorsandprognosisofsmallcelllungcancerpatientsMasterdegreecandidate：KouJinSupervisor：ProfessorSunTaoVice—supervisor：ProfessorJingMingxiMajor：OncologyAbstractobjeetive：smallcelllungcancermalignantdegreeishi曲，stronginvas

2、ion，prognosisispoor,inrecentyearsinthetreatmensurfacedidnotprogressofamazing，thispaperretrospectivelyanalysistheinfluenceofsmallcellprognosticfactorsinlungCanCer．Methods：111etumorhospitalofLiaoningProvincein2003Januaryto2011Decemberweretreatedbyclinicaldataof2

3、18patients、加tllsmallcelllungcancertissuehistologicallyorcytologicallydiagnosed，respectivelyonthegender，age，smokinghistory，KPSscore，weightloss，staging，treatmentmodalities，first—linechemotherapycycles，andeffectofprimarytreatment，laboratoryindexprojectofunivariat

4、eandmultivariateanalysis．SurvivalWasanalyzedusingtheKaplan-Meiermethodtocalculatethesurvivalrateandtomakethesurvivalcurve．UnivariateanalysisWasperformedbyLog—ranktest，andthesinglefactormeaningfulthroughtheCoxriskmodelselectionaffectstheprognosisfactors，P

5、adsignificantdifferenceResults：Inthisstudy，allofthe218patients，1，2，3yearsurvivalrateswere61．5％，22．9％，11．9％，themediansurvivaltimeWas14．5months，152casesofpatients、Ⅳitlllimitedstage，66casesofpatients谢t11extensivestage．Inlimitedstage，1，2，3yearsurvivalrateswere70．4

6、％，27％，14．5％，，themediansurvivaltimeWas16．8months，inextensivestage，1，23yearsurvivalrateswere40．9％，13．6％，6．1％，themediansurvivaltimeWas8．8months，P<0．001，therearesignificantdifferences．KPSscore≥80patientsfor1year，2year，3yearsurvivalrateswere66．9％，27．5％，12．5％，KPS<80

7、patientsforlyear，2year，3yearsurvivalrateswere46．6％，10．3％，10．3％，P

8、therearesignificant3大连医科大学硕士学位论文differences．First-linechemotherapycyclecount<4cycleswerel，2，3yearsurvivalrateswere41．1％，16．1％，7．1％，first—linechemotherapycyclecount≥4cycleswere1，2，3