hmgb1在肝癌发生发展中的初步功能研究

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1、硕士学位论文PreliminaryfunctionalstudiesofHMGBlinthedevelopmentofhepatocellularCarClnomaGraduatecandidatestudent：XiaoJian—BiaoSupervisor：Prof．ChenLong—HuaBackgroundand0bjection：ABSTRACTPrimaryhepatocellularcarcinoma(HCC)isoneofthemostformsofmalignancytodayIts

2、incidenceisthesixthanditsmortalityisthethirdintheworld，whicheveryyearabout62．6millionpeaplesufferit．whodiedoflivercancerabout344000peopleayearinChina，accountingfor55％oflivercancerdeathsintheworld。Relativetothehi}ghmortalityrate，earlylivercancerfoundthat

3、ratioisverylow．Inrecentyears，althoughthetreatmentsforlivercancerupdate(includingsurgicalresection，livertransplantation(olt)，radiationtherapy，interventionaltherapyandminimallyinvasiveablation，etc．)，butnoobviouslyincreasetheoverallefficacyofthetreatmentof

4、livercancer，andrelapseandmetastasisarestillthemainfactorsinfluencingprognosisoflivercancer．Therefore，tostrengthentheresearchofinvasionandmetastasisoflivercancermolecularmechanisms，miningmeaningfultransferofmolecularmarkersoflivercancer，searchingfornewco

5、ntroltargets，iscurrentlyoneofthehotspotoflivercancer．HMGB1belongstoHMG(highmobilitygroup，HMG)ofthemembersofthefamily,inthe1970Sfoundincalfthymus，isakindofabundantnucleoprotein，ABSTRACTmolecularmass，about30kd，existinalleukaryotes．HMGB1geneswerelocatedonc

6、hromosome13q12，containsfourfiveexonsandintrons，codingproteincontaining215aminoacids．HMGB1ishighlyconservative，humanandrodentwithgreaterthan99％aminoacidsequencehomology,exactlythesameasthatofaminoacidsequenceofratsandmiceHMGB1isdifferentbecauseoftheircel

7、lularlocalizationandplaydifferentfunctionsandbiologicaleffect．Currentstudiessuggestthatinadditiontoasa”lateinflammatorymediatorsstartinflammation，secretedtheextracellularHMGB1mayalsoiscloselyrelatedtotheevolutionoftumorandmetastasis【8，9】。Inactivecellspr

8、oliferationanddifferentiationofcells，geneexpressionofHMGB1hadmildincreases，whileinbreastcancer，melanoma，gastrointestinalstromaltumorcelltumors，andpancreaticcancertissues，theexpressionofHMGB1levelsaresignificantlyhigherthanitscorr