ny-eso-1b多肽诱导的抗肝癌免疫及foxp3在肝癌发生发展中的作用和机制研究

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1、博士研究生学位论文论文题目：NY-ESO-1b多肽诱导的抗肝癌免疫及FOXP3在肝癌发生发展中的作用和机制研究姓名：陈衍辉学号：1111110225院（部）：北京大学人民医院专业：内科学（传染病）导师：陈红松研究员副导师：郭远副主任医师完成时间：二O一四年四月11博士研究生学位论文NY-ESO-1b多肽诱导的抗肝癌免疫及FOXP3在肝癌发生发展中的作用和机制研究NY-ESO-1bpeptideinducedanti-hepatomaimmunityandtheroleofFOXP3inthepat

2、hogenesisofhepatocellularcarcinoma———“十一五”科技重大专项（NO.2008ZX10002-019）“十二五”科技重大专项（No.2012ZX10002011-006）国家自然科学基金（No.91029741;No.81001072）北京市自然科学基金（No.5112032）研究生：陈衍辉导师：陈红松研究员副导师：郭远副主任医师北京大学人民医院北京大学肝病研究所完成时间：二O一四年四月11姓名：陈衍辉院系：北京大学人民医院学号：1111110225北京大学医学部

3、学位论文原创性声明和使用授权说明原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进行研究工作所取得的成果。除文中已经注明引用的内容外，本论文不含任何其他个人或集体已经发表或撰写过的作品或成果。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明。本声明的法律结果由本人承担。论文作者签名：日期：年月日学位论文使用授权说明（必须装订在提交学校图书馆的印刷本）本人完全了解北京大学医学部关于收集、保存、使用学位论文的规定，即：l按照学校要求提交学位论文的印刷本和电子版本；l学

4、校有权保存学位论文的印刷本和电子版，并提供目录检索与阅览服务；l学校可以采用影印、缩印、数字化或其它复制手段保存论文；l在不以赢利为目的的前提下，学校可以公布论文的部分或全部内容；l学校可以为存在馆际合作关系的兄弟高校用户提供文献传递服务和交换服务。请选择图书馆发布时间:□即时发布□一年发布二年发布（保密论文在解密后遵守以上规定）论文作者签名：导师签名：日期：年月日11目录中文摘要···························································

5、·······························1英文摘要··························································································6文献综述肝癌免疫治疗的研究现状及进展·············································11引言·························································

6、·······························29第一部分应用NY-ESO-1b多肽疫苗进行肝癌免疫治疗的特殊I期临床研究·····31前言·····························································································31材料和方法·········································································

7、············32结果····························································································47讨论····························································································51第二部分肝癌细胞表达FOXP3在肝癌发生发展中的作用和机制研究············55

8、前言····························································································55材料与方法·····················································································56结果·····················································