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1、延边大学硕士学位论文AbstractAbstractObjective:TostudyandcomparetheeffectsofsesameandatorvastatinonPDGF-Alevelinatherosclerosisinducedbyhighcholesterolinrabbitsdietmodel,andtoexploretheantiatherogenicmechanismofsesamin.Methods:Theexperimentalanimalandgroups:48Japanesewhiterabbits,1weeksafteradaptivefeedingw
2、ithnormaldiet,randomlydividedintonormalcontrolgroup(n=8)andmodelgroup(n=40)accordingtorandomgroupingscale.Normalcontrolgroupwasfedwithnormaldiet,modelgroupfedwithhighcholesteroldiet.5weeksafterfeedinghighcholesteroldiet,4oneswererandomlyselectedtoconfirmthesuccessfulmodel,took36rabbitsforrandomnu
3、mbergrouping,wherein,modelgroup(n=9):highfatdiet×8weeks,sesamintreatmentgroup(n=9):highfatdiet+sesamin4mg/d×8weeksbygavage,atorvastatintreatmentgroup(n=9):highfatdiet+atorvastatin10mg/d×8weeksbygavage,Xuezhikangtreatmentgroup(n=9):highfatdiet+Xuezhikangcapsule0.6/d×8weeksbygavage.Establishmentofa
4、nimalmodel:afteradaptivefeeding,modelgroupviaearveinone-timeinjectionofbovineserumalbumin50mg/kgcausedimmuneinjury,fedwithhighcholesteroldiet,normalcontrolgroupviaearveinone-timeinjectionofphysiologicalsaline5ml.Experimentalmethods:adoptoxidasemethodtotestserumtriglyceride(TG),cholesterol(CHO),lo
5、wdensitylipoprotein(LDL)andhighdensitylipoprotein(HDL)numeriIII万方数据延边大学硕士学位论文Abstractcalvaluesofeachgroupattheendof5weeksand13weeks;adoptimmunohistochemicalmethodtoobservethesituationofpositiveexpressionofaorticwallPDGF-Aofeachgroup;adoptenzymelinkedimmunosorbentassaymethod(ELISA13)totestthelevel
6、sofserumPDGF-Aattheendof13weeks.Results:theserumlipidtest:attheendof13weeks,CHOLDLlevelinsamintreatmentgroup,atorvastatintreatmentgroup,Xuezhikanggroupserumwerelowerthanthatinmodelgroup（P<0.01）,andsesamintreatmentgroup,atorvastatintreatmentgroup,Xuezhikanggroup,normalcontrolgroupserumCHO,TG,HDL,L
7、DLhadnosignificantdifferencewithnormalcontrolgroup(P>0.05).Attheendofthe13weeks,sesamintreatmentgroup,atorvastatintreatmentgroup,XuezhikanggroupserumCHOLDLSignificantlydecreasedthanthatattheendof5weeks,hassignificantdi
