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1、芝麻素对乙醇代谢的影响［收稿日期］2010-04-08（003）［基金项目］芜湖市科技计划基金项目（2008512）作者简介：汪五三，博士研究生，讲师，Tel:13605532565，E-mail：wangyue206@sina.com研究方向：定量药理学与时间药理学汪五三1，栾家杰2（1皖南医学院药理教研室2皖南医学院临床药学研究所皖南医学院弋矶山医院药剂科，安徽芜湖，241002）［摘要］目的：探讨芝麻素对乙醇代谢的影响。方法：1.不同剂量芝麻素（8,23,70mg/kg）对大鼠ig给药14d后，测定灌服
2、乙醇（5g/kg）后不同时间点（0.5,1,2,4,6h）乙醇血液浓度；2.不同剂量芝麻素（10,33,100mg/kg）对小鼠ig给药7d后，测定ip乙醇（2.5g/kg）后不同时间段（1,2,3,4h）动物自主活动次数；3.不同剂量芝麻素（10,33,100mg/kg）对小鼠ig给药7d后，测定腹腔注射乙醇（3.5g/kg）后动物翻正反射消失时间的变化。结果：1.芝麻素23,70mg/kg剂量组可显著降低大鼠血液乙醇浓度；2.芝麻素23,70mg/kg剂量组可使乙醇ig小鼠的自主活动次数增加及翻正反射消失
3、时间缩短。结论：芝麻素可促进乙醇的代谢。［关键词］芝麻素；乙醇；代谢；自主活动；翻正反射EffectsofsesaminonthemetabolismofethanolWangWu-San1LuanJia-Jie2(1DepartmentofPharmacologyinwannanmedicalcollege,2LaboratoryofClincalPharmacyofWannanMedicalCollege,DepartmentofPharmacyinYijishanHospitalofWannanMedi
4、calcollege,Wuhu,241002)[Abstract]Objective:ToinvestigatetheEffectsofsesaminonthemetabolismofethanol.METHEDS:1.Sprague-Dawleyratswereadministratedintragastricallywithsesaminatadoseof8mg/kg,23mg/kgand70mg/kg,respectively.After15doftreatment,ethanolwasadminist
5、ratedintragastrically.Bloodsampleswerecollectedaccordingtotheregulartimescheduleaftersesaminadministrationthroughvenacaudalis.Theconcentrationofnorfloxacinwasdeterminedbyautomaticimmunoassayanalyzer.2.Mciewereadministratedintragastricallywithsesaminatadoseo
6、f10mg/kg,33mg/kgand100mg/kg,respectively.After7doftreatment,ethanolof2.5g/kgwasadministratedbyperitonealinjection.Locomotoractivitywasmeasuredaccordingtotheregulartimescheduleafterethanolwasadministrated.3.Mciewereadministratedintragastricallywithsesaminata
7、doseof10mg/kg,33mg/kgand100mg/kg,respectively.After7doftreatment,ethanolof3.5g/kgwasadministratedbyperitonealinjection.Durationoflossofrightingreflexwasmeasuredafterethanolwasadministrated.Results:1.Seaminatthedoseof23mg/kgand70mg/kgcanreducethebloodconcent
8、rationofethonalinmice.2.Seaminatthedoseof33mg/kgand100mg/kgcanincreasethelocomotoractivityinducedbyethanolinmice.3.Seaminatthedoseof33mg/kgand100mg/kgcanshortentheethanol-induceddurationoflossofrightin
