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1、延边大学硕士学位论文AbstractAbstractObjective:ToexplortheinfluenceofsesameonIL-1αinatheroscleroticrabbitmodel.Methods:44Japanesewhiterabbits,1weeksafteradaptivefeedingwithnormaldiet,randomlydividedintonormalcontrolgroup(n=8)andmodelgroup(n=40)accordingtorandomgroupingscale
2、.Normalcontrolgroupwasfedwithnormaldiet,modelgroupfedwithhighcholesteroldiet.5weeksafterfeedinghighcholesteroldiet,4oneswererandomlyselectedtoconfirmthesuccessfulmodel,took36rabbitsforrandomnumbergrouping,modelgroup(n=9):wherein,sesamintreatmentgroup(n=9):highfat
3、diet+sesamin4mg/d×8weeksbygavage,atorvastatintreatmentgroup(n=9):highfatdiet+atorvastatin10mg/d×8weeksbygavage,Xuezhikangtreatmentgroup(n=9):highfatdiet+Xuezhikangcapsule0.6/d×8weeksbygavage.Establishmentofanimalmodel:afteradaptivefeeding,modelgroupviaearveinone-
4、timeinjectionofbovineserumalbumin50mg/kgcausedimmuneinjury,fedwithhighcholesteroldiet,normalcontrolgroupviaearveinone-timeinjectionofphysiologicalsaline5ml.Experimentalmethods:adoptoxidasemethodtotestserumtriglyceride(TG),cholesterol(CHO),lowdensitylipoprotein(LD
5、L)andhighdensitylipoprotein(HDL)numericalvaluesofeachgroupattheendof5weeksand13weeks;adoptimmunohistochemicalmethodtoobservethesituationofpositiveexpressionofaorticwallIL-1αofeachgroup;adoptenzymelinkedimmunosorbentassaymethod(ELISA13)totestthelevelsofserumIL-1αa
6、ttheendof13weeks.Results:theserumlipidtest:attheendof13weeks,sesamintreatmentgroup,atorvastatintreatmentgroup,XuezhikanggroupIII万方数据延边大学硕士学位论文AbstractserumCHO、TG、LDLwerelowerthanthatofmodelgroup,andsesamintreatmentgroup,atorvastatintreatmentgroup,Xuezhikanggroups
7、erumCHO、TG、LDLhadnosignificantdifferencewithnormalcontrolgroup(P>0.05).Immuno-histochemistry:esamingroupandatorvastatingroupmainaorticwallIL-1αpositivecellsexpressionwassignificantlylowerthanthatinmodelgroupbuthigherthannormalcontrolgroup,therewassignificantdiffe
8、rence(P<0.05);sesamingroupandatorvastatingroupIL-1αpositivecellsexpressiondidn’tshowsignificantdifference(P>0.05).TestingofserumIL-1αlevels:sesamingroupandator
