异丙酚对全身高温疗法致兔急性脑损伤的保护作用

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1、山东大学硕士学位论文ofinjurydegreeofthefourgroup：Bgroup>Cgroup>Dgroup>Agroup．(5)InfluenceofWBHontheexpressionofH0一linrabbitvascularendotheliumacellSofbrain：OnlYuntingedcellandlOW一1eveltinctcellSappearedingroupA．HO一1一immunoreactivecellSwhichweredyedbrownappearedingroupB，CandD，andVastofthemappearedi

2、ngroupB．UsemeangreyvaluetoevaluatetheexpressionofH0—1，highmeangreyvaluemeanslowexpressionofho一1．ThereexistSignificantlydifferencebetweenA、B、C、Dgroupinmeangreyvalue(PCgroup>Dgroup>Bgroup．ThatiStosay，thereexistsignificantlydif

3、ferencebetweenA、B、C、DgroupintheexpressionofHO-1invascularendotheliumacelis(PDgroup>Cgroup>Agroup．(6)InfluenceofWBHontheformationofcellapoptosis：OnlyfewubiquitouslyexpressedtinctcelIsappearedingroupA．Specificexpressedapoptos

4、iscellwhichweredyedbrownappearedingroupB、CandD．ThereexistsignificantlydifferencebetweenA、B、C、DgroupintheapoptosiSofbraincortexnervecellS(PCgroup>Dgroup>Agroup．(7)correlationanalysiS：NervecellapoptosisiSinpositirecorrelation

5、withtheconcentrationofMDAinbrainwhenthemomentanustemperatureresumed(r=0．769，P

6、cidosiSandformationoftoomuchoxygenfreeradicalS，enhance1iquidperoxidation：bringheatinjury，tissuedropsyandincreasethenumberofcellapoptosisgreatlyinbrain：enhancetheexpressionofhemeoxygenase一1inrabbitvascularendotheliumacelisofbrain．Propofolcanrestraineffectivelythestrongheatstress，6山东大学硕士学位

7、论文maintainthestabilizationofvitalsignsandblood—gas．reducetheextentofacid—baseimbalance，reducetheOFRsandtheexcessiveexpressionofhemeoxygenase—lirlrabbitvascularendotheliumacellSofCNSwhichprobablyleadstotheapoptosiSofbraincelis．A11thesestronglysuggestedthatoxygenationisasso