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1、肝豆状核变性患者胆囊收缩功能与血浆CCK、VIP水平关系的研究徐磊,蔡永亮,陈怀珍,徐国存,李俊,葛青,张静安徽中医学院第一附属医院神经内科合肥市230031通讯作者:蔡永亮，230031，安徽省合肥市梅山路117号，安徽中医学院第一附属医院神经内科，CYL9797@.sina电话：0551-2838706RelationshipStudyofTheGallbladderContractionRateAndTheContentsofPlasmaCCK,VIPofHLDPatients.XuLei,CaiYong-liang,ChenHuai-
2、zhen,XuGuo-cu,LiJun,Geqing,ZhangJing.DeparmentofNeurologyofFirstAffiliatedHospitalofAnhuiCollegeofTraditinalChineseMedicine,Hefei,230031,ChinaCorrespondingauthor:CaiYong-liang,DeparmentofNeurologyofFirstAffiliatedHospitalofAnhuiCollegeofTraditinalChineseMedicine,117#Meishan
3、Road,Hefei,230031,China.CYL9797@sina.comAbstractAIM:ToinvestigatethecorrelationbetweentheContractileFunctionofGallbladderandthecontentsofplasmacholecystokinin(CCK)andvasoactiveintestinalpeptide(VIP)inHepatolenticulardegeneration(HLD)patients.METHODS:ThecontentsofplasmaCCKan
4、dVIPin37HLDpatientsweredeter-minedbyradioimmunoassay(RIA),andcomparedwiththoseinthehealthypersons.ThesurfaceareasofgallbladderofHLDpatientsmeasuredbyB-UltrasoundbeforeandafterFatDiets.RESULTS:ThecontentsofplasmaCCKandVIPinHLDpatientsweresignificantlyhigherthanthoseinhealthy
5、control(P﹤0.05).ThesurfaceareasofgallbladderofHLDpatientsbeforeFatDietsweresignificantlylargerthanthoseinhealthycontrol(P﹤0.05).NosignificantchangeinThesurfaceareasofgallbladderbeforeFatDietsbetweenHLDgroupandcontrolgroup(P﹥0.05),thegallbladdercontractionrateinHLDgroupweres
6、ignificantlylessthanthoseincontrolgroup(P﹤0.05).CONCLUSION:ThehighcontentsofplasmaCCKandVIPplaysanimportantroleintheContractileFunctionofGallbladderofHLDpatients.KeyWords:HLD；contractilefunctionofgallbladder；CCK；VIP摘要目的：探讨HLD患者血浆胆囊收缩素（CCK）、血管活性肠肽（VIP）水平与胆囊收缩功能的关系。方法：选择符合诊断标
7、准的HLD患者37例，37位健康人为对照组。采用放射免疫法检测两组血浆CCK、VIP水平，B超测定两组脂餐前后胆囊面积，计算胆囊收缩率。结果：HLD组血浆CCK、VIP水平显著高于对照组（P﹤0.05）；HLD组脂餐前胆囊面积（BS）显著小于对照组（P﹤0.05），两组脂餐后胆囊面积（AS）无显著差异性（P﹥0.05），HLD胆囊收缩率（CR）显著小于对照组（P﹤0.05）。结论：HLD患者血浆CCK、VIP水平对其胆囊收缩功能产生影响。关键词：肝豆状核变性胆囊收缩功能胆囊收缩素血管活性肠肽0引言肝豆状核变性（hepatolenticular
8、degeneration，HLD）是一种常染色体隐性遗传的铜代谢障碍性疾病，临床上主要表现为进行性加重的锥体外系症状、肝硬化、肾功能损害及角膜K-F环形成等。HLD
