活血化瘀通络中药对糖尿病肾病大鼠的干预作用与对at2r的影响

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1、万方数据英文摘要significantlydecreased(尸0．05)，NosignificantdifferencebetweenIgroupandZYgroup俨>O．05)．Comparedwiththenormalgroup，theTGofmodelgroupwassignificantlyincreased(尸

2、5)．Comparedwiththemodelgroup，theTGoftreatmentgroupsweresignificantlydecreased(P>O．05)，NosignificantdifferencebetweenIgroupandZYgroupP>O．05)．Comparedwiththenormalgroup，theTCofmodelgroupwassignificantlyincreased(P

3、ongtheM，ZYandIgroups(尸>O．05)．Comparedwiththenormalgroup，theBUNofmodelgroupwassignificantlyincreased俨O．05)．Compar

4、edwiththenormalgroup，theScrofmodelgroupWassignificantlyincreased(尸<0．05)．Comparedwiththemodelgroup，theScroftreatmentgroupswereslightlydecreased俨>O．05)．6Morphologicalchangesinrenaltissue6．1PhotomicrographsofrenalcortexfromratsindifferentgroupsTheglomer

5、ularstructureofnormalgroupwascompleteandclear,andtherewerenoobviouslyhypertrophy．Themodelgroupshowedthat，glomerularhypertrophy,thebasementmembraneofglomerularthickened，thecellofmesangialproliferation，mesangialmatrixincreased，mesangialareabroadened．The

6、pathologicalchangesofthetreatmentgroupswerelighterthanthemodelgroup．6．2UltrastructuralchangesofglomerulifromratsindifferentgroupsundertransmissionelectronmicroscopeTheglomerularstructureofnormalgroupWascompleteandthebasementmembraneofglomerularwasclea

7、r．Endothelialcell，footprocess，andmesangialareadidnotshowsignificantchange．Themodelgroupshowedthat：theglomerularbasementmembranewasthickened，endothelialcellandthefootprocesswereextensivefusion．Thetreatmentgroupsshowedthe万方数据英文摘要similarchanges，butthedeg

8、reewaslighterthanmodelgroup．7AT2RexpressedinrenaltissuebyimmunohistochemistryAllgroupsshowedthatAT2Rexpressedinrenaltissue．AT2Rexpressedmainlylocatedinvascularendothelialcellandglomerularendothelialcell．Theresultshowedthatcomparedwiththenormal