资源描述：
《非小细胞肺癌患者e某某4-某某k基因表达与临床特征与近期生存的关系》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、2.Themutationratebetweeninmalepatients(6.8%)andfemalepatients(15.8%)hadnosignificantdifference(P=0.291).Themutationratebetween60yearsofageorolderpatientsandage<60yearsisprovednosignificantdifference(P=0.782).Thesmokingrateofmutation(0%)andnotsmokingrate(17%)werestatisticallysignifi
2、cant(P=0.023).Themutationrate(13.1%)ofadenocarcinoma、squamouscellcarcinoma、largecellcarcinomageneandothertypesis13.1%、90%、0%、16.67%,respectively,buttherewerenogreatlysignificantdifferencesbetweenthefourgroups(P=0.782).Thepresenceoftumormetastasisgenemutationrate(11.67%)andtheabsenc
3、eofthat(9.1%)showednosignificantdifference(P=0.737).StageIgenemutationrate(10%),stageIIgenemutationrate(0%),stageIIIgenemutationrate(13%),stageIVgenemutationrate(11.1%),buttherewerenosignificantdifferencesbetweenthefour(P=0.846).Themutationrateof+-EGFRgroup(2.6%)andEGFRgroup(18.2%)
4、wassignificantdifferences(P=0.033).3.ThisstudywasuntilApril30,2014,atotalof9patientswerelosttofollow-up,heremainingpatientshadcompletefollow-updata,werefollowedupfor6-37months,therewere29casesofdeath,including4caseofEML4-ALKgenemutationand25casesinnogenemutationgroup.Twogroupsofove
5、rallsurvivaltimewererespectively23months(95%CI,22-24months)and21months(95%CI,18-24months),P=0.769,theyarenostatisticaldifference.Colusions:1.theexperimentsweredonein82casesofNSCLCpatientswithEML4-ALKfusiongenedetection,including9casesofmutation,themutationratewas10.97%,inwhichdoubl
6、esitemutationin3cases,specificforE13;A20mutationin9cases,E6;A20in1cases,E20;A20mutationin2cases.2.EML4-ALKfusiongenemutationtendtowomen,notsmoking,andnomutationofEGFRgeneinadenocarcinomapatients.Age,thediseasestageandthetumor8万方数据metastasisarenostatisticaldifferencebetweenEML4-ALKf
7、usiongenemutationornot.3.EML4-ALKfusiongenemutationisnotasanindependentfactorinevaluatingtheprognosisofnonsmallcelllung.Keywords:nonsmallcelllungcancerEML4-ALKfusiongeneclinicalcharacteristicssurvival9万方数据非小细胞肺癌患者EML4-ALK基因表达与临床特征及生存的关系前言肺癌是当今全球最常见的恶性肿瘤之一，统计资料显示其发病率呈逐年上升[1]趋势，已有报道表
8、明肺癌的发病率和死亡率位于世界恶性肿瘤首位。因此肺癌
