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时间:2020-05-12
《非小细胞肺癌患者外周血循环肿瘤细胞与临床特征关系的初步研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、临床与病理杂志20151ClinPath0lRes⋯,35(1)http://w⋯w⋯~lcb~1.n⋯e43doi:10.3978/j.issn.2095—6959.2015.01.013Viewthisarticleat:http://dx.doi.org/10.3978/j.issn.2095-6959.2015.01.013非小细胞肺癌患者外周血循环肿瘤细胞与临床特征关系的初步研究万佳蔚,沈洪远。,黄红字。,韩志君。,严子禾。,高明珠,黄新祥(1.江苏大学基础医学与医学技术学院,江苏镇江212013;2.无锡市第二人民医院检验科,江苏无锡21
2、4002)【摘要】目的:评价非小细胞肺癌(non—smallcelllungcancer,NSCLC)患者的外周静脉血循环肿瘤细胞(circulatingtumorcells,CTC)计数的临床应用价值。方法:收集2013年1月一2013年12月无锡市第二人民医院诊断的50例NSCLC作为研究对象,同时收集良性肺部疾病患者3s例及28例体检健康者。采集上述各研究组静脉血标本,检测静脉血CTC的数量,≥8.7单位判定为阳性。分析CTC计数与患者年龄、性别、病理类型及临床分期之间的关系。结果:NSCLC患者CTC计数显著高于良性肺部疾病对照组和健康对照组
3、。NSCLC患者外周血中CTC与患者性别、年龄、病理类型无明显关系(P>O.05),CTC数值随着肿瘤临床分期递进而增加(P4、an,HUANGHongyu,HANZhijun2,YANZihe。GAOMingzhuJHUANGXinxiangSchoolofMedicalScienceandLaboratoryMedicin6]iangsuUniversity,Zhenjiang212013;2.DepartmentofclinicallaboratoryofWuxiNo.2people'sHospital,Wuxi214002,China)AbstractObjective:Toevaluatetheclinicalvalueofcirculatingtumorcells5、(CTC)countinperipheralvenousbloodofpatientswithnon—smallcelllungcarcinoma(NSCLC).Methods:Totally50patientswithNSCLCinWuxiNo.2people'sHospitalwereselectedforstudyfromJanuary2013toDecember2013,35patientswithlungbenigntumorand28normalvolunteerswereselectedasthecontrolgroups.CTCcol6、lectedfrom3mLvenousbloodofallpeopleabovewerecounted.Patientswith8.7unitsOrmoreCTCwerejudgedtobepositive.TherelationshipbetweenthepositiverateofCTCandtheage,sexJpathologicaltypeandclinicalstagewasanalyzed.Results:CTC收稿日期(Dateofreception):2014—10—27通信作者(Correspondingauthor):高明珠,E7、maihgaomingzhujewel@163.com基金项目(Foundationitem):无锡市医院管理中心医学科技项目(xGzxQ_1310)。"ibisworkwsupportedbyScienceandTechnologyProjectsofWuxiCity(YGZXQ.1310)P_R.China.临床与病理杂志201535(1)http://www.1cb1.netcountwassignificantlyhigherinNSCLCpatientsthaninbenignlungpatientsandhealthycontrols.C8、TCcountinNSCLCpatientswasrarelyrelatedtothesexJageorth
4、an,HUANGHongyu,HANZhijun2,YANZihe。GAOMingzhuJHUANGXinxiangSchoolofMedicalScienceandLaboratoryMedicin6]iangsuUniversity,Zhenjiang212013;2.DepartmentofclinicallaboratoryofWuxiNo.2people'sHospital,Wuxi214002,China)AbstractObjective:Toevaluatetheclinicalvalueofcirculatingtumorcells
5、(CTC)countinperipheralvenousbloodofpatientswithnon—smallcelllungcarcinoma(NSCLC).Methods:Totally50patientswithNSCLCinWuxiNo.2people'sHospitalwereselectedforstudyfromJanuary2013toDecember2013,35patientswithlungbenigntumorand28normalvolunteerswereselectedasthecontrolgroups.CTCcol
6、lectedfrom3mLvenousbloodofallpeopleabovewerecounted.Patientswith8.7unitsOrmoreCTCwerejudgedtobepositive.TherelationshipbetweenthepositiverateofCTCandtheage,sexJpathologicaltypeandclinicalstagewasanalyzed.Results:CTC收稿日期(Dateofreception):2014—10—27通信作者(Correspondingauthor):高明珠,E
7、maihgaomingzhujewel@163.com基金项目(Foundationitem):无锡市医院管理中心医学科技项目(xGzxQ_1310)。"ibisworkwsupportedbyScienceandTechnologyProjectsofWuxiCity(YGZXQ.1310)P_R.China.临床与病理杂志201535(1)http://www.1cb1.netcountwassignificantlyhigherinNSCLCpatientsthaninbenignlungpatientsandhealthycontrols.C
8、TCcountinNSCLCpatientswasrarelyrelatedtothesexJageorth
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