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1、-------2.Themutationratebetweeninmalepatients(6.8%)andfemalepatients(15.8%)hadnosignificantdifference(P=0.291).Themutationratebetween60yearsofageorolderpatientsandage<60yearsisprovednosignificantdifference(P=0.782).Thesmokingrateofmutation(0%)andnotsmokingrate(17%)werestatisticallysignificant
2、(P=0.023).Themutationrate(13.1%)ofadenocarcinoma、squamouscellcarcinoma、largecellcarcinomageneandothertypesis13.1%、90%、0%、16.67%,respectively,buttherewerenogreatlysignificantdifferencesbetweenthefourgroups(P=0.782).Thepresenceoftumormetastasisgenemutationrate(11.67%)andtheabsenceofthat(9.1%)sh
3、owednosignificantdifference(P=0.737).StageIgenemutationrate(10%),stageIIgenemutationrate(0%),stageIIIgenemutationrate(13%),stageIVgenemutationrate(11.1%),buttherewerenosignificantdifferencesbetweenthefour(P=0.846).ThemutationrateofEGFR+group(2.6%)andEGFR-group(18.2%)wassignificantdifferences(
4、P=0.033).3.ThisstudywasuntilApril30,2014,atotalof9patientswerelosttofollow-up,heremainingpatientshadcompletefollow-updata,werefollowedupfor6-37months,therewere29casesofdeath,including4caseofEML4-ALKgenemutationand25casesinnogenemutationgroup.Twogroupsofoverallsurvivaltimewererespectively23mon
5、ths(95%CI,22-24months)and21months(95%CI,18-24months),P=0.769,theyarenostatisticaldifference.Colusions:1.theexperimentsweredonein82casesofNSCLCpatientswithEML4-ALKfusiongenedetection,including9casesofmutation,themutationratewas10.97%,inwhichdoublesitemutationin3cases,specificforE13;A20mutation
6、in9cases,E6;A20in1cases,E20;A20mutationin2cases.2.EML4-ALKfusiongenemutationtendtowomen,notsmoking,andnomutationofEGFRgeneinadenocarcinomapatients.Age,thediseasestageandthetumor8-----------万方数据-----------metastasisarenostatisticaldifferencebetweenEML4-ALKfusiongenemutationornot.2.EML4-ALKfusi
7、ongenemutationisnotasanindependentfactorinevaluatingtheprognosisofnonsmallcelllung.Keywords:nonsmallcelllungcancerEML4-ALKfusiongeneclinicalcharacteristicssurvival9-----------万方数据-----------非小细胞肺癌患者EML4-ALK基因表达与临床特征及生存的关系前言肺癌是当今全球最常见的恶性肿瘤之一，统
