贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭的临床-研究

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1、山东大学硕士学位论文ClinicalresearchofBenazeprilcombinedwithmetoprololinthetreatmentofelderlyhypertensivepatientswithheartfailureMh．D．StudentGaoLiAdvisorProf．ZhongMingABSTRACTBackgroundHypertensionisoneofthemostcommoncardiovasculardiseaseinclinical，thepathologycharacteristicandthec

2、linicalsyndromeofsystemicarterialpressurerise，longdurationandtargetorgandamagecanleadtostroke，myocardialinfarction，heartfailureandchronickidneydiseasecomplicationssuchas，notonlycausesdamage，thefatalityrateishigh,andonthefamilyandsociety，hasbecomeamajorpublichealthproblemw

3、orldwide，atthesametimeasthepopulationages，elderlypatientswithhighblood‘。‘b，．earbloodpressureISmcreasmgyearbyyear．Andoldagehypertensionhasits●uniqueclinicalcharacteristics：(1)pulsepressureandhighisolatedsystolichypertensionprevalencerate；(2)bloodpressurefluctuations；(3)eas

4、yhappeningpseudohypertension；(4)complicationsandcomplications：moreeasilycomplicatedwithhypertensiveheartdisease，heartfailure，kidneyfailure，Canincreaseperipheralvasculardisease，stroke，arrhythmia,diabetes，hyperlipidemia，suchasalzheim&sdiseaseprogression．Heartfailure(HF)isth

5、emostcommoncomplicationsinelderlypatientswithhypertension，accordingtothesamplingstatisticsofOurcountryin2003senileheartfailureincidenceis0．9％；AccordingtotheAmericanheartassociation(触-tA)2005statisticalreport，intheUnitedStateshasabout5millionpatientswithheartfailure，heartf

6、ailureonthenumberofannualgrowthfor550000．HypertensionisimportantcauseofCHF，reportsfromFraminghamshowthatTheriskofheartfailureinHypertensionpatientsis6timesofthenormalbloodpressure．AnincreasedincidenceofCHFwhensystolicordiastolicbloodpressureincreasesofelderlymenandwomen，7

7、5％ofpatientswithCHFcausedbyhypertension，5yearsafterthe4山东大学硕士学位论文occurrenceofCHFmortalityratesashighas50％．Inshort，hypertensionisabigharmfortheelderly，hypertensioninelderlypatients谢t11hypertensioninheartfailureaswellasrelatedsignificantlyincreasedthedangerofdeath．．Theheart

8、ofthepatients谢tllllighbloodpressurebycontinuousbloodpressureincreasesCanincreasetheleftventricle