贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭的临床分析

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1、山东大学硕士学位论文ClinicalresearchofBenazeprilcombinedwithmetoprololinthetreatmentofelderlyhypertensivepatientswithheartfailureMh．D．StudentGaoLiAdvisorProf．ZhongMingABSTRACTBackgroundHypertensionisoneofthemostcommoncardiovasculardiseaseinclinical，thepathologycharacteristicandtheclinicalsyndromeofsystemica

2、rterialpressurerise，longdurationandtargetorgandamagecanleadtostroke，myocardialinfarction，heartfailureandchronickidneydiseasecomplicationssuchas，notonlycausesdamage，thefatalityrateishigh,andonthefamilyandsociety，hasbecomeamajorpublichealthproblemworldwide，atthesametimeasthepopulationages，elderlypat

3、ientswithhighblood‘。‘b，．earbloodpressureISmcreasmgyearbyyear．Andoldagehypertensionhasits●uniqueclinicalcharacteristics：(1)pulsepressureandhighisolatedsystolichypertensionprevalencerate；(2)bloodpressurefluctuations；(3)easyhappeningpseudohypertension；(4)complicationsandcomplications：moreeasilycompli

4、catedwithhypertensiveheartdisease，heartfailure，kidneyfailure，Canincreaseperipheralvasculardisease，stroke，arrhythmia,diabetes，hyperlipidemia，suchasalzheim&sdiseaseprogression．Heartfailure(HF)isthemostcommoncomplicationsinelderlypatientswithhypertension，accordingtothesamplingstatisticsofOurcountryin

5、2003senileheartfailureincidenceis0．9％；AccordingtotheAmericanheartassociation(触-tA)2005statisticalreport，intheUnitedStateshasabout5millionpatientswithheartfailure，heartfailureonthenumberofannualgrowthfor550000．HypertensionisimportantcauseofCHF，reportsfromFraminghamshowthatTheriskofheartfailureinHyp

6、ertensionpatientsis6timesofthenormalbloodpressure．AnincreasedincidenceofCHFwhensystolicordiastolicbloodpressureincreasesofelderlymenandwomen，75％ofpatientswithCHFcausedbyhypertension，5yearsafterthe4山东大学硕士学位论文occurrenceofCHFmortalityratesashighas50％．Inshort，hypertensionisabigharmfortheelderly，hypert

7、ensioninelderlypatients谢t11hypertensioninheartfailureaswellasrelatedsignificantlyincreasedthedangerofdeath．．Theheartofthepatients谢tllllighbloodpressurebycontinuousbloodpressureincreasesCanincreasetheleftventricle