非酒精性脂肪性肝炎患者血清肝纤维化指标的变化

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1、浙江大学硕士研究生论文LiverfibrosismarkersinnonalcoholicfattyliverdiseaseMedicalSchoolofZhejiangUniversityInternalmedicine(Gastroenterology)Graduateclass：HongXiao-fallhltor：ProfessorLiYon—ruingAbstractBackgroundandIaims：Withtheincreaseoftheincidencerateandhavingthepotentialtoprogresstoend-sta

2、geliverdisease，nonalcoholicsteatohepatitis(NASH)hasbeentakenseriously,TherearemanyreportsaboutthepathogenesisofNASH．progressingtoliverfibrosis．Liverbiopsyisthekeyexaminationforthediagnosisoffibrosis．However,inclinicalpractice,theuseofliverbiopsyhasseverallimimtiom．Ithasbeensuggeste

3、dthatserummarkersofextracellularmam。xmaybeaccuratemarkersofhepaticfibrosis，butlessreportisaboutthemleoftheserumliverfibrosismarkersinNASH．Inthisstudy,we·wouldliketoobservethechangeofserumlevelsofhyaluronicacid∞A)，"t‘ypeIIIpmcollagen(PCIII)，laminin(LN)，andtypeIVcollagen(IV-C)innonal

4、coholicfattyliverfNAFL)andNASHanduseReceiverOperatingCharacteristic(ROC)curvesinevaluationofserumfibrosismarkersforhepaticfibrosistorealizethediagnosticeffectofserumHA，PC-Ill，LNandIV—CinNAFLandNASH．Subjects：l12patientswithnonalcoholicfattyliverdisease(NFALD)selectedaccordingt0thefo

5、llowingrequirments：(1)non-alcoholabusehabit(weeklyaveragealcoholintakeislessthan409)；(2)nospecialdiseaseswhichCarlleadtOfatty1liversuchasvirushepatitis、totalparenteralnutritionandetal；(3)somepatientswillcomplainofgeneralizedfatigue，abdominaldistension，mildrightupperquadrantpainande

6、ta1．Onphysicalexmnination，hepatameglyandsplenomegalymaybe5浙江大学硕士研究生论文mostcomITlOnlaboratoryabnormalityiselevatedalanineaminotramferase(ALT)，oftenacompanyinghighaspartateaninotransferase(AST)，gamma-glutamyltransferase(GGT)and．triglycerides；⑤Bultrasonicvariablesareacurdingtothediagno

7、sticstandardoffattyliver．55patientswithNFALselectedaccordingtothefollowing：equirments：(1)conformingto①，②．③，⑤o卜therequirmentsofNAFLD；(2)nomallaboratorytestofliverfunction．57．patientswithNASHselectedaccordingtothefollowingrequirments(1)conformingto①’②，③，⑤oftherequirmentsofNAFLD；(2)AL

8、Tisusuallyoverthantwotimes