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1、286例非酒精性脂肪肝患者血液生化指标和肝纤维化指标的分析作者：肖桂初，黄维加，刘键，李振华，肖晓友，莫凡【关键词】非酒性脂肪肝；血液生化指标；肝纤维化指标 ［摘要］目的：探讨血液生化和肝纤维化指标在非酒精性脂肪肝患者临床诊断中的意义。方法：对符合B超诊断的286例非酒精性脂肪肝患者进行血液生化指标（TG、TC、HDLc、LDLc、ALT、AST、GGT、ALP）和肝纤维化指标(PCⅢ、HA、CⅣ、LN)检测，并以体检健康者作为对照。结果：非酒精性脂肪肝患者TG和TC水平均高于对照组(P<0.01)，HDLc和LDLc与对照组相比分别呈下降
2、和升高的趋势；重度非酒精性脂肪肝组ALT、AST和GGT明显升高(P<0.01)，ALP升高不显著（P>0.05)；非酒精性脂肪肝患者PCⅢ、HA、CⅣ和LN均高于健康组(P<0.05)，重度组与轻、中度组之间PCⅢ、HA、CⅣ和LN差异均有显著性(P<0.01)，中度脂肪肝与轻度脂肪肝之间PCⅢ、HA、CⅣ和LN差异无显著性(P>0.05)。结论：非酒性脂肪肝患者多项血液生化指标异常，重度非酒性脂肪肝患者尚存在不同程度的肝纤维化趋向。多项血液生化指标的检测可作为非酒精性脂肪肝筛查的重要依据，而肝纤维化指标的检测可进一
3、步作为非酒精性脂肪肝病情监控和疗效评估的重要依据。9 ［关键词］非酒性脂肪肝；血液生化指标；肝纤维化指标 AssessmentoftheClinicalSignificanceofSerumBiochemistryandLiverFibrosisIndexesin286PatientswithNonalcoholicFattyLiverDisease Abstract：ObjectiveToassesstheclinicalsignificanceofserumbiochemistryandliverfibrosisindexesinthep
4、atientswithnonalcoholicfattyliverdisease.MethodsBiochemistryindexes,TG,TC,HDLc,LDLc,ALT,AST,GGTandALP,andliverfibrosisindexes,PCⅢ,HA,CⅣandLN,weredeterminedin286patienteswithnonalcoholicfattyliverdiseasediagnosedwithBultrasonicechography,andtake100normalvolunteerascontrol.Resul
5、tsSerumTGandTClevelsinthepatientswithnonalcoholicfattyliverdiseaseweremuchhigherthanthoseinthecontrol.SerumHDLclevelwasincreased,butLDLclevelwasdecreasedinthepatientswithnonalcoholicfattyliverdisease.SerumALT,ASTandGGTlevelsinseverefattylivercasesweresignificantlyraisedandthes
6、erumALPlevelswerenotraised.SerumlevelofPCⅢ,HA,CⅣandLNinthepatientswithnonalcoholicfattyliverdiseaseweresignificantlyhigherthan9thoseofheathysubjects.thedifferencesofPCⅢ,HA,CⅣandLNbetweenthepatientswithsevereandmoderateormildfattyliverdiseaseweresignificant.ButthedifferenceofPC
7、Ⅲ,HA,CⅣandLNbetweenthepatientswithmildandmoderatefattyliverdiseasewasnotsignificant.ConclusionMultiplebiochemicalindexeswereabnormalinthepatientswithnonalcoholicfattyliverdisease,andthepatientswithseverenonalcoholicfattyliverdiseasehasatrendofliverfibrosis.Determinationofmulti
8、plebiochemicalindexescouldprovideausefultoolforScreeningnonal
